The mission of the program project Is to establish the role of the brainstem and interconnected brain regions In the causation and pathogenesis of the sudden Infant death syndrome (SIDS), the leading cause of postneonatal infant mortality in the United States today. The Administrative Core A within the program project serves as the administrative framework for the effective and coordinated execution of the program as a whole In order to fulfill this mission. Core A provides the administrative Infrastructure that allows for the scientific interactions of the investigators and trainees to progress In an unencumbered and focused manner towards meeting the program's specific alms with excellence and In a timely manner. It also ensures financial and grant management, as well as coordination of the program's Advisory Boards, both external and Internal. It Is based In the Department of Pathology, Children's Hospital Boston, and is overseen by Dr. Hannah C. Kinney, Director of the program project. Staff members of Core A are Ms. Mary Gavin, Core manager who serves as the liaison to the subcontracting institutions for billing management and other issues;she also coordinates Issues related to personnel, and grant management policies and regulations. In addition, the staff Includes Ms. Ann Tano who serves as Administrative Assistant to Dr. Kinney and Ms. Gavin, and who Is Involved In support of all administrative tasks. The Internal Advisory Board Is coordinated by Core A and consists of the senior investigators of the program. Core A also serves as the liaison to the External Advisory Board which consists of 5 external scienfists with expertise in neuropathology, neuroscience, cardiorespiratory and sleep physiology, and genetics. This external board brings together the different members'expertise to consult on the scientific objectives and research alms of the program. Administrative Core A Is essential to the progress of the program project, with a proven track record In critical support to the program project since its inception In 1998.

Public Health Relevance

The mission of the program project is to elucidate the role of the brainstem and Interconnected brain regions in the sudden infant death syndrome (SIDS), the leading cause of post neonatal Infant mortality in the United States today. The Administrative Core A provides the administrative Infrastructure and support In order for the successful achievement of this mission, and Is thereby relevant to overall public health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD036379-17
Application #
8739294
Study Section
Special Emphasis Panel (ZHD1-DSR-Z)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
17
Fiscal Year
2014
Total Cost
$99,491
Indirect Cost
$65,628
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Dosumu-Johnson, Ryan T; Cocoran, Andrea E; Chang, YoonJeung et al. (2018) Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery. Elife 7:
Babb, Jessica A; Linnros, Sofia E; Commons, Kathryn G (2018) Evidence for intact 5-HT1A receptor-mediated feedback inhibition following sustained antidepressant treatment in a rat model of depression. Neuropharmacology 141:139-147
Guo, Yue-Ping; Commons, Kathryn G (2017) Serotonin neuron abnormalities in the BTBR mouse model of autism. Autism Res 10:66-77
Hennessy, Morgan L; Corcoran, Andrea E; Brust, Rachael D et al. (2017) Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex. J Neurosci 37:1807-1819
Darnall, Robert A; Chen, Xi; Nemani, Krishnamurthy V et al. (2017) Early postnatal exposure to intermittent hypoxia in rodents is proinflammatory, impairs white matter integrity, and alters brain metabolism. Pediatr Res 82:164-172
Tenpenny, Richard C; Commons, Kathryn G (2017) What Gene Mutations Affect Serotonin in Mice? ACS Chem Neurosci 8:987-995
Cerpa, Veronica J; Wu, Yuanming; Bravo, Eduardo et al. (2017) Medullary 5-HT neurons: Switch from tonic respiratory drive to chemoreception during postnatal development. Neuroscience 344:1-14
Ehlinger, Daniel G; Commons, Kathryn G (2017) Altered Cav1.2 function in the Timothy syndrome mouse model produces ascending serotonergic abnormalities. Eur J Neurosci 46:2416-2425
Panzini, Chris M; Ehlinger, Daniel G; Alchahin, Adele M et al. (2017) 16p11.2 deletion syndrome mice perseverate with active coping response to acute stress - rescue by blocking 5-HT2A receptors. J Neurochem 143:708-721
Commons, Kathryn G; Cholanians, Aram B; Babb, Jessica A et al. (2017) The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior. ACS Chem Neurosci 8:955-960

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