Abstract

The purpose of this portion of the application are to 1) construct microarrays containing target DNAs representing the entire genome of Dictyostelium discoideum, 2) to use these arrays to determine expression profiles for wide type Dictyostelium grown under a variety of conditions, and 3) to use expression profiles as a molecular phenotype with which to characterize the potential functions of thousands of genes mutagenized in Project I of this proposal. These data will be used in Project III to cluster phenotypes and lead to testable hypotheses regarding the function of these genes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
1P01HD039691-01
Application #
6478453
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2001-06-19
Project End
2006-05-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Dinh, Christopher; Farinholt, Timothy; Hirose, Shigenori et al. (2018) Lectins modulate the microbiota of social amoebae. Science 361:402-406
Hirose, Shigenori; Chen, Gong; Kuspa, Adam et al. (2017) The polymorphic proteins TgrB1 and TgrC1 function as a ligand-receptor pair in Dictyostelium allorecognition. J Cell Sci 130:4002-4012
Swatson, William S; Katoh-Kurasawa, Mariko; Shaulsky, Gad et al. (2017) Curcumin affects gene expression and reactive oxygen species via a PKA dependent mechanism in Dictyostelium discoideum. PLoS One 12:e0187562
Stajdohar, Miha; Rosengarten, Rafael D; Kokosar, Janez et al. (2017) dictyExpress: a web-based platform for sequence data management and analytics in Dictyostelium and beyond. BMC Bioinformatics 18:291
Rosengarten, Rafael D; Santhanam, Balaji; Kokosar, Janez et al. (2017) The Long Noncoding RNA Transcriptome of Dictyostelium discoideum Development. G3 (Bethesda) 7:387-398
Zhang, Xuezhi; Zhuchenko, Olga; Kuspa, Adam et al. (2016) Social amoebae trap and kill bacteria by casting DNA nets. Nat Commun 7:10938
Zitnik, Marinka; Zupan, Blaz (2016) COLLECTIVE PAIRWISE CLASSIFICATION FOR MULTI-WAY ANALYSIS OF DISEASE AND DRUG DATA. Pac Symp Biocomput 21:81-92
Katoh-Kurasawa, Mariko; Santhanam, Balaji; Shaulsky, Gad (2016) The GATA transcription factor gene gtaG is required for terminal differentiation in Dictyostelium. J Cell Sci :
Zitnik, Marinka; Zupan, Blaz (2016) Jumping across biomedical contexts using compressive data fusion. Bioinformatics 32:i90-i100
Chen, Xinlu; Köllner, Tobias G; Jia, Qidong et al. (2016) Terpene synthase genes in eukaryotes beyond plants and fungi: Occurrence in social amoebae. Proc Natl Acad Sci U S A 113:12132-12137

Showing the most recent 10 out of 64 publications