Abstract

The Laboratory Core will be established to act as the center for the collection, processing, distribution, storage, and testing of specimens obtained from the clinic sites in support of studies being conducted in the projects. The primary objectives of the Laboratory Core are to: (i) act as the central specimen processing and repository for the study of specific specimens as well as specimen extracts, (ii) perform virologic and immunologic assays as indicated in the subprojects, and (iii) to be an intermediary for bring new laboratory technology to the program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
1P01HD040539-01
Application #
6467548
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2001-04-23
Project End
2006-03-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Cook, Judith A (2011) Associations between use of crack cocaine and HIV-1 disease progression: research findings and implications for mother-to-infant transmission. Life Sci 88:931-9
Spear, Gregory T; Kendrick, Sabrina R; Chen, Hua Y et al. (2011) Multiplex immunoassay of lower genital tract mucosal fluid from women attending an urban STD clinic shows broadly increased IL1ß and lactoferrin. PLoS One 6:e19560
St John, Elizabeth P; Zariffard, M Reza; Martinson, Jeffrey A et al. (2009) Effect of mucosal fluid from women with bacterial vaginosis on HIV trans-infection mediated by dendritic cells. Virology 385:22-7
Anzinger, Joshua J; Olinger, Gene G; Spear, Gregory T (2008) Donor variability in HIV binding to peripheral blood mononuclear cells. Virol J 5:95
Spear, Gregory T; Sikaroodi, Masoumeh; Zariffard, M Reza et al. (2008) Comparison of the diversity of the vaginal microbiota in HIV-infected and HIV-uninfected women with or without bacterial vaginosis. J Infect Dis 198:1131-40
Spear, Gregory T; Zariffard, M Reza; Cohen, Mardge H et al. (2008) Vaginal IL-8 levels are positively associated with Candida albicans and inversely with lactobacilli in HIV-infected women. J Reprod Immunol 78:76-9
Mares, Debra; Simoes, Jose A; Novak, Richard M et al. (2008) TLR2-mediated cell stimulation in bacterial vaginosis. J Reprod Immunol 77:91-9
Novak, Richard M; Donoval, Betty A; Graham, Parrie J et al. (2007) Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection. Clin Vaccine Immunol 14:1102-7
St John, Elizabeth P; Martinson, Jeff; Simoes, Jose A et al. (2007) Dendritic cell activation and maturation induced by mucosal fluid from women with bacterial vaginosis. Clin Immunol 125:95-102
Fox-Canale, Andrea M; Hope, Thomas J; Martinson, Jeffrey et al. (2007) Human cytomegalovirus and human immunodeficiency virus type-1 co-infection in human cervical tissue. Virology 369:55-68

Showing the most recent 10 out of 27 publications