Program Director/Principal Investigator (Last, First, Middle): SADOVSKY, YOEL B. Core A: Summary The goal of the proposed program project is to examine genetic, epigenetic, and cellular controls of placental metabolism and function, focusing on placental storage and metabolism of metabolic fuels. Within this context, this core will serve as the central leadership and oversight office for the administration and coordination of all activities associated with the proposed project program grant. The primary functions of the Administrative Core will be to 1) facilitate interaction and communication among affiliated research groups, and with the external advisory committee 2) coordinate infrastructure and shared resources that support all three research projects and 3) ensure that all administrative, reports, safety and compliance needs are met expeditiously and efficiently. The small yet vital administrative core will serve this goal by general planning, coordination, initiation, and management of all programmatic aspects. As synergy among the three research groups is central to the programmatic success of the project, the core will assure the efficient communication and collaboration among the three projects. This will also include the conduct of regular PI meetings as well as shared laboratory meetings at monthly intervals. Using economies-of-scale principles, the administrative core will oversee the efficient use of purchasing and use of external resources at the University of Pittsburgh and other entities. The core will assure the submission and maintenance of lACUC, IRB protocols, and other safety-related protocols, track publications, and provide progress reports and other administrative reviews to the NIH, as required. The core will convene and coordinate the interaction with program's external advisory committee. Finally, the core's PI will serve to resolve any conflicts of interests that might arise during the course of the program. The core will provide data collection and sharing tools for the research groups and cores through creation and maintenance of an internal web site, coordinated with the MWRI IT staff. The administrative core will also facilitate investigator interactions with the appropriate offices within MWRI and the University of Pittsburgh to provide appropriate external sharing of data and model organisms, in compliance with NIH policies.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1-DSR-Z)
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Magee-Women's Research Institute and Foundation
United States
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Bildirici, Ibrahim; Schaiff, W Timothy; Chen, Baosheng et al. (2018) PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia. Endocrinology 159:3937-3949
Shalom-Barak, Tali; Liersemann, Jaclyn; Memari, Babak et al. (2018) Ligand-Dependent Corepressor (LCoR) Is a Rexinoid-Inhibited Peroxisome Proliferator-Activated Receptor ?-Retinoid X Receptor ? Coactivator. Mol Cell Biol 38:
Lee, Sungeun; Pallerla, Srinivas R; Kim, Suyeon et al. (2016) Esrrb-Cre excises loxP-flanked alleles in early four-cell embryos. Genesis 54:53-61
Ouyang, Yingshi; Bayer, Avraham; Chu, Tianjiao et al. (2016) Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity. Placenta 47:86-95
Mishima, Takuya; Sadovsky, Elena; Gegick, Margaret E et al. (2016) Determinants of effective lentivirus-driven microRNA expression in vivo. Sci Rep 6:33345
Himes, K P; Young, A; Koppes, E et al. (2015) Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism. Placenta 36:389-96
Shaffer, Ben; McGraw, Serge; Xiao, Siyu C et al. (2015) The DNMT1 intrinsically disordered domain regulates genomic methylation during development. Genetics 199:533-41
Koppes, Erik; Himes, Katherine P; Chaillet, J Richard (2015) Partial Loss of Genomic Imprinting Reveals Important Roles for Kcnq1 and Peg10 Imprinted Domains in Placental Development. PLoS One 10:e0135202
Larkin, J C; Sears, S B; Sadovsky, Y (2014) The influence of ligand-activated LXR on primary human trophoblasts. Placenta 35:919-24
Mohammadyani, Dariush; Tyurin, Vladimir A; O'Brien, Matthew et al. (2014) Molecular speciation and dynamics of oxidized triacylglycerols in lipid droplets: Mass spectrometry and coarse-grained simulations. Free Radic Biol Med 76:53-60

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