Abstract

This program has a common interest in responses of large and small vessels and of their endothelial and smooth muscle cells to injury. Fundamental questions are being asked related to basic pathologic processes that may be involved in atherosclerosis. Mechanisms that permit or stimulate cell replication, cell migration and cellular interactions are being investigated. The potential role of mechanical and toxic injuries, of the metabolic products of xenobiotics and the mechanism whereby herpesviruses may produce proliferative lesions in animals and human beings are being investigated. The program includes studies of the nature of changes in ploidy of smooth muscle with age and hypertension studies. Mechanisms of interaction of leukocytes, endothelial cells, of the HDL apoprotein and ApoSAA are also being investigated. A wide range of methods are being used including cell culture, histoimmunocytochemistry, flow cytophotometry, scanning electron microscopy and molecular probes for viral and amyloid genes in cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL003174-31
Application #
3097360
Study Section
(SRC)
Project Start
1978-03-01
Project End
1988-02-29
Budget Start
1986-03-01
Budget End
1987-02-28
Support Year
31
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Qin, Wan; Roberts, Meredith A; Qi, Xiaoli et al. (2016) Depth-resolved 3D visualization of coronary microvasculature with optical microangiography. Phys Med Biol 61:7536-7550
Mahoney Jr, William M; Fleming, Jo Nadine; Schwartz, Stephen M (2011) A unifying hypothesis for scleroderma: identifying a target cell for scleroderma. Curr Rheumatol Rep 13:28-36
Naumova, Anna V; Reinecke, Hans; Yarnykh, Vasily et al. (2010) Ferritin overexpression for noninvasive magnetic resonance imaging-based tracking of stem cells transplanted into the heart. Mol Imaging 9:201-10
Minami, Elina; Castellani, Chiara; Malchodi, Laura et al. (2010) The role of macrophage-derived urokinase plasminogen activator in myocardial infarct repair: urokinase attenuates ventricular remodeling. J Mol Cell Cardiol 49:516-24
Paige, Sharon L; Osugi, Tomoaki; Afanasiev, Olga K et al. (2010) Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS One 5:e11134
Nourse, Marilyn B; Halpin, Daniel E; Scatena, Marta et al. (2010) VEGF induces differentiation of functional endothelium from human embryonic stem cells: implications for tissue engineering. Arterioscler Thromb Vasc Biol 30:80-9
Moreno-Gonzalez, Alicia; Korte, F Steven; Dai, Jin et al. (2009) Cell therapy enhances function of remote non-infarcted myocardium. J Mol Cell Cardiol 47:603-13
Anderl, Jeff N; Robey, Thomas E; Stayton, Patrick S et al. (2009) Retention and biodistribution of microspheres injected into ischemic myocardium. J Biomed Mater Res A 88:704-10
Stevens, K R; Kreutziger, K L; Dupras, S K et al. (2009) Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue. Proc Natl Acad Sci U S A 106:16568-73
Stevens, Kelly R; Pabon, Lil; Muskheli, Veronica et al. (2009) Scaffold-free human cardiac tissue patch created from embryonic stem cells. Tissue Eng Part A 15:1211-22

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