Abstract

The Exercise Core Facility will provide two different approaches, voluntary wheel running and low-frequency tonic pacing of the motor nerve, to augment contractile activity in muscles of intact mice. Both of these procedures are associated with changes in endogenous gene expression consistent with fiber type transformation. These procedures have previously been developed, tested and successfully used in wild type and transgenic animals under the supervision of Dr. Bassel-Duby at UT Southwestern. In addition, we will perform studies on isolated skeletal muscle function to study the isometric and isotonic contractile function of mouse skeletal muscle.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL006296-45
Application #
7074742
Study Section
Project Start
Project End
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
45
Fiscal Year
2005
Total Cost
$374,195
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Chang, Audrey N; Battiprolu, Pavan K; Cowley, Patrick M et al. (2015) Constitutive phosphorylation of cardiac myosin regulatory light chain in vivo. J Biol Chem 290:10703-16
Thomas, Gail D (2015) Functional sympatholysis in hypertension. Auton Neurosci 188:64-8
Martin, Elizabeth A; Barresi, Rita; Byrne, Barry J et al. (2012) Tadalafil alleviates muscle ischemia in patients with Becker muscular dystrophy. Sci Transl Med 4:162ra155
Fadel, Paul J; Farias Iii, Martin; Gallagher, Kevin M et al. (2012) Oxidative stress and enhanced sympathetic vasoconstriction in contracting muscles of nitrate-tolerant rats and humans. J Physiol 590:395-407
Stull, James T; Kamm, Kristine E; Vandenboom, Rene (2011) Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle. Arch Biochem Biophys 510:120-8
Sachan, Nita; Dey, Asim; Rotter, David et al. (2011) Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart. Circ Res 108:437-45
Massare, Jorge; Berry, Jeff M; Luo, Xiang et al. (2010) Diminished cardiac fibrosis in heart failure is associated with altered ventricular arrhythmia phenotype. J Cardiovasc Electrophysiol 21:1031-7
Tandan, Samvit; Wang, Yanggan; Wang, Thomas T et al. (2009) Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel. Circ Res 105:51-60
Huang, Jian; Shelton, John M; Richardson, James A et al. (2008) Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophy. J Biol Chem 283:19748-56
Tannous, Paul; Zhu, Hongxin; Nemchenko, Andriy et al. (2008) Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation 117:3070-8

Showing the most recent 10 out of 167 publications