Abstract

This Program Project focuses on mechanisms and therapy of electrical dysfunction of the heart, particularly those rhythm disturbances which have lethal potential. The projects are grouped under four sections: Electrophysiology, Cellular and Subcellular; Metabolism: Relationship to Electrical Function; Myocardial Blood Flow: Relationships to Electrophysiology and Clinical Arrhythmias; and Anatomic and Hemodynamic Environment of Arrhythmias. It is the aim of the Program Project to foster integrated studies in the above areas in order that the information derived will have clinical applicability and will be exchangeable across interdisciplinary lines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL006308-27
Application #
3097386
Study Section
Heart, Lung, and Blood Research Review Committee A (HLBA)
Project Start
1978-03-01
Project End
1988-02-29
Budget Start
1987-03-01
Budget End
1988-02-29
Support Year
27
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Fukunaga, K; Muller, D; Ohmitsu, M et al. (2000) Decreased protein phosphatase 2A activity in hippocampal long-term potentiation. J Neurochem 74:807-17
Neumann, J; Boknik, P; DePaoli-Roach, A A et al. (1998) Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility. J Mol Cell Cardiol 30:1991-2002
Zhao, Y; Boguslawski, G; Zitomer, R S et al. (1997) Saccharomyces cerevisiae homologs of mammalian B and B' subunits of protein phosphatase 2A direct the enzyme to distinct cellular functions. J Biol Chem 272:8256-62
Csortos, C; Zolnierowicz, S; Bako, E et al. (1996) High complexity in the expression of the B' subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoforms. J Biol Chem 271:2578-88
Altschuld, R A; Starling, R C; Hamlin, R L et al. (1995) Response of failing canine and human heart cells to beta 2-adrenergic stimulation. Circulation 92:1612-8
Pitcher, J A; Payne, E S; Csortos, C et al. (1995) The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. Proc Natl Acad Sci U S A 92:8343-7
Zolnierowicz, S; Csortos, C; Bondor, J et al. (1994) Diversity in the regulatory B-subunits of protein phosphatase 2A: identification of a novel isoform highly expressed in brain. Biochemistry 33:11858-67
Shima, H; Tohda, H; Aonuma, S et al. (1994) Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells. Proc Natl Acad Sci U S A 91:9267-71
Dutil, E M; Keranen, L M; DePaoli-Roach, A A et al. (1994) In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation. J Biol Chem 269:29359-62
Tang, P M; Bondor, J A; Swiderek, K M et al. (1991) Molecular cloning and expression of the regulatory (RG1) subunit of the glycogen-associated protein phosphatase. J Biol Chem 266:15782-9

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