This core has the goal of providing radionuclides and synthetic precursors for Project 1 and radiopharmaceuticals for Projects 2-4. To this end two cyclotrons are maintained and radiopharmaceuticals labeled with oxygen-15, carbon-11 and fluorine-18. Copper-60 will be produced for a subproject in Project 1. The Core carried out the appropriate quality control testing. The Core also carries out metabolite analysis for Project 3. Developmental work will be continued on 11C-ethyliodide preparation and on the development of analytical techniques related to Project 4.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL013851-38
Application #
6467593
Study Section
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
Budget End
Support Year
38
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Peterson, Linda R; Herrero, Pilar; Coggan, Andrew R et al. (2015) Type 2 diabetes, obesity, and sex difference affect the fate of glucose in the human heart. Am J Physiol Heart Circ Physiol 308:H1510-6
Zhou, Dong; Chu, Wenhua; Xu, Jinbin et al. (2014) Synthesis, [¹?F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorg Med Chem 22:1700-7
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Herrero, Pilar; Laforest, Richard; Shoghi, Kooresh et al. (2012) Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humans. J Nucl Med 53:994-1001
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Solingapuram Sai, Kiran Kumar; Kil, Kun-Eek; Tu, Zhude et al. (2012) Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-? receptors. Bioorg Med Chem Lett 22:6233-6
Cheng, Ju-Chieh Kevin; Shoghi, Kooresh; Laforest, Richard (2012) Quantitative accuracy of MAP reconstruction for dynamic PET imaging in small animals. Med Phys 39:1029-41
Peterson, Linda R; Saeed, Ibrahim M; McGill, Janet B et al. (2012) Sex and type 2 diabetes: obesity-independent effects on left ventricular substrate metabolism and relaxation in humans. Obesity (Silver Spring) 20:802-10
Zhou, Dong; Chu, Wenhua; Dence, Carmen S et al. (2012) Highly efficient click labeling using 2-[¹?F]fluoroethyl azide and synthesis of an ¹?FN-hydroxysuccinimide ester as conjugation agent. Nucl Med Biol 39:1175-81

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