Abstract

Vector Core The Vector Core is a service facility supported in part by the University of Iowa College of Medicine but also by RO1s, program projects (PPGs), Center Grants (P30s) and SCORs. The facility provides an integrative function in facilitating gene transfer studies in both applied and basic research. GOALS The specific aims of the Vector Core for this PPG proposal are i) to prepare working stocks of previously generated recombinant viruses for investigators to perform gene transfer experiments, ii) test all viruses for wild type contamination and pfu/particle ration, iii) generate new recombinant viruses as needed including cloning into shuttle vectors, iv) assist in the evaluation of initial gene transfer studies by helping set up molecular and/or enzymatic assays. By providing these services, the Vector Core substantially reduced the overall cost and time of setting up routine vector production in each investigators laboratory.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL014388-27
Application #
6109374
Study Section
Project Start
1999-01-01
Project End
1999-12-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
27
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Sabharwal, Rasna; Mason, Bianca N; Kuburas, Adisa et al. (2018) Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension. J Cereb Blood Flow Metab :271678X17751352
Harwani, Sailesh C (2018) Macrophages under pressure: the role of macrophage polarization in hypertension. Transl Res 191:45-63
Shaffer Jr, Joseph J; Johnson, Casey P; Fiedorowicz, Jess G et al. (2018) Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states. Brain Imaging Behav 12:837-847
Xue, Baojian; Beltz, Terry G; Guo, Fang et al. (2018) Sex differences in maternal gestational hypertension-induced sensitization of angiotensin II hypertension in rat offspring: the protective effect of estrogen. Am J Physiol Regul Integr Comp Physiol 314:R274-R281
Holwerda, Seth W; Holland, Marshall T; Reddy, Chandan G et al. (2018) Femoral vascular conductance and peroneal muscle sympathetic nerve activity responses to acute epidural spinal cord stimulation in humans. Exp Physiol 103:905-915
Persons, Jane E; Coryell, William H; Solomon, David A et al. (2018) Mixed state and suicide: Is the effect of mixed state on suicidal behavior more than the sum of its parts? Bipolar Disord 20:35-41
Kopf, Phillip G; Phelps, Laura E; Schupbach, Chad D et al. (2018) Differential effects of long-term slow-pressor and subpressor angiotensin II on contractile and relaxant reactivity of resistance versus conductance arteries. Physiol Rep 6:
Zhang, Yu-Ping; Huo, Yan-Li; Fang, Zhi-Qin et al. (2018) Maternal high-fat diet acts on the brain to induce baroreflex dysfunction and sensitization of angiotensin II-induced hypertension in adult offspring. Am J Physiol Heart Circ Physiol 314:H1061-H1069
Johnson, Casey P; Christensen, Gary E; Fiedorowicz, Jess G et al. (2018) Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1? mapping. Bipolar Disord 20:381-390
Hardy, Rachel N; Simsek, Zinar D; Curry, Brandon et al. (2018) Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. Physiol Behav 192:90-97

Showing the most recent 10 out of 175 publications