The mouse is clearly the choice of experimental organisms to study complex genetic process such as blood pressure regulation, ion homeostasis, and pathogenesis of kidney disease. Many researchers on University of Iowa campus use the genetically modified mice to test hypotheses relating to gene function in disorders of kidney function and blood pressure regulation. The Animal Models Core will act as a centralized facility to conduct the breeding and genotyping of mice constructed by PPG investigators. In this way this Core will ensure high quality and consistency in the genetically modified animals. The Animal Models Core will be an extension of the University of Iowa College of Medicine Gene Targeting Core Facility. The Gene Targeting Facility was established in 1998 and is now under the direction of Dr. Baoli Yang. Dr. Yang has 15 years experience in gene targeting and will serve as Director of the PPG Animal Models Core. Dr. Cao has over 10 years experience in mouse related research, from the gene targeting to small animal surgeries, will serve as Co Director. Importantly, Dr. Yang has a major scientific interest in normal and abnormal kidney physiology and blood pressure regulation. Dr. Yang has taken an intense interest in the development of the infrastructure that has lead to the development of this Animal Models Core for the PPG at the University of Iowa. The Gene Targeting Facility has generated over 120 different liens of mice, serving over 40 faculty members at the University of Iowa and more than 10 investigators outside of the University. The Gene Targeting Facility provides expertise and centralized instrumentation for the generation, breeding and analysis of genetically modified mice. An investigator starting a new project has immediate access to current and effective procedures in the generation and analysis of knock-out animals without the need for the investigator's staff to master time-consuming and technically demanding procedures. The Animal Models Core also provides a means for sharing new information on experimental strategies and methodology and avoids the unnecessary duplication of personnel and expensive equipment which results from the needs of multiple individual laboratories.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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University of Iowa
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Zhang, Yu-Ping; Huo, Yan-Li; Fang, Zhi-Qin et al. (2018) Maternal high-fat diet acts on the brain to induce baroreflex dysfunction and sensitization of angiotensin II-induced hypertension in adult offspring. Am J Physiol Heart Circ Physiol 314:H1061-H1069
Johnson, Casey P; Christensen, Gary E; Fiedorowicz, Jess G et al. (2018) Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1? mapping. Bipolar Disord 20:381-390
Hardy, Rachel N; Simsek, Zinar D; Curry, Brandon et al. (2018) Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. Physiol Behav 192:90-97
Lane-Cordova, Abbi D; Kalil, Graziela Z; Wagner, Christopher J et al. (2018) Hemoglobin A1c and C-reactive protein are independently associated with blunted nocturnal blood pressure dipping in obesity-related prediabetes. Hypertens Res 41:33-38
Larson, Robert A; Chapleau, Mark W (2018) Increased cardiac sympathetic activity: Cause or compensation in vasovagal syncope? Clin Auton Res 28:265-266
Tong, Brian; Abosi, Oluchi; Schmitz, Samantha et al. (2018) Bipolar disorder and related mood states are not associated with endothelial function of small arteries in adults without heart disease. Gen Hosp Psychiatry 51:36-40
Zeng, Wei-Zheng; Marshall, Kara L; Min, Soohong et al. (2018) PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. Science 362:464-467
DuBose, Lyndsey E; Boles Ponto, Laura L; Moser, David J et al. (2018) Higher Aortic Stiffness Is Associated With Lower Global Cerebrovascular Reserve Among Older Humans. Hypertension 72:476-482
Holwerda, Seth W; Luehrs, Rachel E; Gremaud, Allene L et al. (2018) Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety. J Neurophysiol 120:11-22
Sabharwal, Rasna; Mason, Bianca N; Kuburas, Adisa et al. (2018) Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension. J Cereb Blood Flow Metab :271678X17751352

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