Abstract

Function: This core provides a range of services that are essential to the success of the overall program: * In vivo studies of pulmonary and systematic circulation. * Operation of hypo- and hyperbaric chambers. * Coordination of management of animals in large animal hypobaric chambers at Colorado State University in Fort Collins, CO. * Maintenance of breeding colonies for inbred mice. * Preparation and renewal of animal Services. Provided: In vivo studies of pulmonary and systematic circulation: The Animal Core provides a vital bridge linking in vitro studies in isolated organs and vessels and cultured cells to the in vivo setting. This permits the important test of relevance of concepts developed in reduced preparations to intact animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL014985-35
Application #
7371915
Study Section
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
35
Fiscal Year
2007
Total Cost
$159,372
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Stenmark, Kurt R; Graham, Brian B (2018) Urocortin 2: will a drug targeting both the vasculature and the right ventricle be the future of pulmonary hypertension therapy? Cardiovasc Res 114:1057-1059
Madhavan, Krishna; Frid, Maria G; Hunter, Kendall et al. (2018) Development of an electrospun biomimetic polyurea scaffold suitable for vascular grafting. J Biomed Mater Res B Appl Biomater 106:278-290
Stenmark, Kurt R; Frid, Maria G; Graham, Brian B et al. (2018) Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension. Cardiovasc Res 114:551-564
Schäfer, Michal; Kheyfets, Vitaly O; Barker, Alex J et al. (2018) Reduced shear stress and associated aortic deformation in the thoracic aorta of patients with chronic obstructive pulmonary disease. J Vasc Surg 68:246-253
Graham, Brian B; Kumar, Rahul; Mickael, Claudia et al. (2018) Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol 59:479-489
Wick, Marilee J; Harral, Julie W; Loomis, Zoe L et al. (2018) An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse. J Vis Exp :
Reisz, Julie A; Barrett, Alexander S; Nemkov, Travis et al. (2018) When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies. Expert Rev Proteomics 15:293-309
Friesen, Richard M; Schäfer, Michal; Ivy, D Dunbar et al. (2018) Proximal pulmonary vascular stiffness as a prognostic factor in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging :
Stenmark, Kurt R; Tuder, Rubin M (2018) Peroxisome Proliferator-activated Receptor ? and Mitochondria: Drivers or Passengers on the Road to Pulmonary Hypertension? Am J Respir Cell Mol Biol 58:555-557
Jiang, Xinguo; Tian, Wen; Tu, Allen B et al. (2018) Endothelial HIF-2? is Required for the Maintenance of Airway Microvasculature. Circulation :

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