This is a renewal application from an established Program- Project which began with a cardiopulmonary theme but now focuses entirely on coronary circulatory control and pathophysiology. Current program structure includes four research areas and four supporting core units. Project I addresses mechanisms postulated to control coronary pressure- flow behavior, using experimental designs intended to deal with potentially confounding issues and thereby resolve currently controversial points. Project II continues ongoing studies of coronary input impedance, extending observations during diastole to the full cardiac cycle and also addressing systolic-diastolic flow interactions, effects of intramyocardial capacitance and the distribution of arterial components of capacitance. Project III addresses factors modulating autoregulatory responses to acute and chronic reductions in regional coronary artery pressure in conscious animals, emphasizing interactions among flow, function and pressure near the lower auto-regulatory limit of the traditional steady-state pressure-flow relationship. Project IV reflects the currently intense clinical and experimental interest in coronary reperfusion. Earlier studies of myocardial injury and recent animal and human studies during reperfusion indicate that myoglobin is a useful agent for detecting reperfusion noninvasively and evaluating several pertinent consequences. Overall Program-Project strategy continues to emphasizes scientific interaction among investigators whose personal research interests and efforts cross interdisciplinary lines, and whose activities are facilitated by collaborative endeavor in shared core laboratory facilities. The intend result is an innovative, stable program having a synergistic effect on both basic and applied coronary research.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Research Review Committee A (HLBA)
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State University of New York at Buffalo
Schools of Medicine
United States
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Rajagopalan, S; Dube, S; Canty Jr, J M (1995) Regulation of coronary diameter by myogenic mechanisms in arterial microvessels greater than 100 microns in diameter. Am J Physiol 268:H788-93
Canty Jr, J M; Smith Jr, T P (1995) Adenosine-recruitable flow reserve is absent during myocardial ischemia in unanesthetized dogs studied in the basal state. Circ Res 76:1079-87
Canty Jr, J M; Schwartz, J S (1994) Nitric oxide mediates flow-dependent epicardial coronary vasodilation to changes in pulse frequency but not mean flow in conscious dogs. Circulation 89:375-84
Mates, R E; Judd, R M (1993) Models for coronary pressure-flow relationships. Adv Exp Med Biol 346:153-61
Smith Jr, T P; Canty Jr, J M (1993) Modulation of coronary autoregulatory responses by nitric oxide. Evidence for flow-dependent resistance adjustments in conscious dogs. Circ Res 73:232-40
Canty Jr, J M (1993) Measurement of myocardial perfusion by fast computed tomography. Am J Card Imaging 7:309-16
Mates, R E (1993) The coronary circulation. J Biomech Eng 115:558-61
Satoh, S; Klocke, F J; Canty Jr, J M (1993) Tone-dependent coronary arterial-venous pressure differences at the cessation of venous outflow during long diastoles. Circulation 88:1238-44
Canty Jr, J M (1993) Methods of assessing coronary blood flow and flow reserve. Am J Card Imaging 7:222-32
Farhi, E R; Klocke, F J; Mates, R E et al. (1991) Tone-dependent waterfall behavior during venous pressure elevation in isolated canine hearts. Circ Res 68:392-401

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