Abstract

This Program Project addresses a critical supramolecular system in Vascular Biology, the molecular pathways responsible for hemostasis and inflammation, thrombogenesis, thrombolysis, and immune mediated vascular inflammation, implicated as well in vascular diseases including atherosclerosis, and thought to play a meaningful role in cell adhesion, movement in embryogenesis and tissue development. The assembly of these molecular pathways on cell surfaces is a thematic issue. The central hypothesis is that the basis of important vascular diseases rests in the cell biology and molecular biology of the vascular system and the solutions rest in the structure of the proteins and their receptors. The concept that there are active stimuli for transcription, secretion, cell surface assembly and structural control of cell function are at the core of our approach to vascular diseases. Elucidation of the molecules that are responsible for initiation, propagation and the observed effect has proceed to the analysis of the structural basis of function.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL016411-20
Application #
3097562
Study Section
Heart, Lung, and Blood Research Review Committee B (HLBB)
Project Start
1992-06-20
Project End
1994-05-31
Budget Start
1993-06-01
Budget End
1994-05-31
Support Year
20
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Kurakula, Kondababu; Koenis, Duco S; Herzik Jr, Mark A et al. (2018) Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity. Haematologica 103:1073-1082
Mackman, Nigel; Davis, George E (2011) Blood coagulation and blood vessel development: is tissue factor the missing link? Arterioscler Thromb Vasc Biol 31:2364-6
Lin, Rui; Roychowdhury-Saha, Manami; Black, Chris et al. (2011) Control of RNA processing by a large non-coding RNA over-expressed in carcinomas. FEBS Lett 585:671-6
Niessen, Frank; Furlan-Freguia, Christian; Fernández, José A et al. (2009) Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood 113:2859-66
Sen, Mehmet; Herzik, Mark; Craft, John W et al. (2009) Spectroscopic Characterization of Successive Phosphorylation of the Tissue Factor Cytoplasmic Region. Open Spectrosc J 3:58-64
Ruf, W; Furlan-Freguia, C; Niessen, F (2009) Vascular and dendritic cell coagulation signaling in sepsis progression. J Thromb Haemost 7 Suppl 1:118-21
van den Berg, Y W; van den Hengel, L G; Myers, H R et al. (2009) Alternatively spliced tissue factor induces angiogenesis through integrin ligation. Proc Natl Acad Sci U S A 106:19497-502
Zhang, Qing; Petersen, Helle H; Ostergaard, Henrik et al. (2009) Molecular dynamics simulations and functional characterization of the interactions of the PAR2 ectodomain with factor VIIa. Proteins 77:559-69
Zhang, Qing; Sanner, Michel; Olson, Arthur J (2009) Shape complementarity of protein-protein complexes at multiple resolutions. Proteins 75:453-67
Potty, Ajish S R; Kourentzi, Katerina; Fang, Han et al. (2009) Biophysical characterization of DNA aptamer interactions with vascular endothelial growth factor. Biopolymers 91:145-56

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