Abstract

This research project is a multidisciplinary program for the study of the microcirculation. The principal emphasis is on study of the regulation of blood flow through the capillaries and arterioles and the mechanisms whereby substances are exchanged between the blood and tissues. The local regulatory mechanisms (metabolic and myogenic) will be examined in detail through a variety of experimental studies. The behavior of these mechanisms will be characterized with the aid of analytical models. A close working relationship between the experimental and analytical phases of the study is planned. A similar approach will be taken in studies of exchange, with experimental and theoretical aspects closely related. The program will work toward a comprehensive model of regulatory and exchange phenomena in the microcirculation. The program also includes a core facility for development of new techniques for the study of circulation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL017421-12
Application #
3097586
Study Section
Heart, Lung, and Blood Research Review Committee A (HLBA)
Project Start
1974-09-01
Project End
1989-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
12
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85722

  Publications

Toth, Andras; Pal, Miklos; Intaglietta, Marcos et al. (2007) Contribution of anaerobic metabolism to reactive hyperemia in skeletal muscle. Am J Physiol Heart Circ Physiol 292:H2643-53
Richmond, K N; Shonat, R D; Lynch, R M et al. (1999) Critical PO(2) of skeletal muscle in vivo. Am J Physiol 277:H1831-40
Pal, M; Toth, A; Ping, P et al. (1998) Capillary blood flow and tissue metabolism in skeletal muscle during sympathetic trunk stimulation. Am J Physiol 274:H430-40
Shonat, R D; Johnson, P C (1997) Oxygen tension gradients and heterogeneity in venous microcirculation: a phosphorescence quenching study. Am J Physiol 272:H2233-40
Baldwin, A L; Wilson, L M; Gradus-Pizlo, I et al. (1997) Effect of atherosclerosis on transmural convection an arterial ultrastructure. Implications for local intravascular drug delivery. Arterioscler Thromb Vasc Biol 17:3365-75
Secomb, T W; Hsu, R (1996) Motion of red blood cells in capillaries with variable cross-sections. J Biomech Eng 118:538-44
Toth, A; Pal, M; Tischler, M E et al. (1996) Are there oxygen-deficient regions in resting skeletal muscle? Am J Physiol 270:H1933-9
Schubert, V; Schubert, P A; Breit, G et al. (1995) Analysis of arterial flowmotion in spinal cord injured and elderly subjects in an area at risk for the development of pressure sores. Paraplegia 33:387-97
Kerger, H; Torres Filho, I P; Rivas, M et al. (1995) Systemic and subcutaneous microvascular oxygen tension in conscious Syrian golden hamsters. Am J Physiol 268:H802-10
Secomb, T W (1995) Mechanics of blood flow in the microcirculation. Symp Soc Exp Biol 49:305-21

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