Abstract

This program project is devoted to the mechanisms of pulmonary ventilation and bloodflow, and the relationsips between ventilation, bloodflow and pulmonary gas exchange. Mechanisms of ventilation are being investigated during high frequency mechanical ventilation, during changes in gravitational loading, and in patients with asthma and other types of lung disease. Control of pulmonary bloodflow is being investigated during alveolar hypoxia, lung edema, and at different stages of lung inflation. Pulmonary gas exchange is being studied in patients with various types of lung disease, in diving mammals, in the avian lung, and in theoretical models in which ventilation and bloodflow are mismatched.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL017731-11
Application #
3097600
Study Section
Heart, Lung, and Blood Research Review Committee A (HLBA)
Project Start
1975-02-01
Project End
1990-01-31
Budget Start
1985-02-01
Budget End
1986-01-31
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Richardson, Russell S; Wary, Claire; Wray, D Walter et al. (2015) MRS Evidence of Adequate O? Supply in Human Skeletal Muscle at the Onset of Exercise. Med Sci Sports Exerc 47:2299-307
Esposito, F; Wagner, P D; Richardson, R S (2015) Incremental large and small muscle mass exercise in patients with heart failure: evidence of preserved peripheral haemodynamics and metabolism. Acta Physiol (Oxf) 213:688-99
Olfert, I Mark; Malek, Moh H; Eagan, Tomas M L et al. (2014) Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy. BMC Pulm Med 14:106
Tang, Kechun; Murano, George; Wagner, Harrieth et al. (2013) Impaired exercise capacity and skeletal muscle function in a mouse model of pulmonary inflammation. J Appl Physiol 114:1340-50
Poole, David C; Copp, Steven W; Ferguson, Scott K et al. (2013) Skeletal muscle capillary function: contemporary observations and novel hypotheses. Exp Physiol 98:1645-58
Koga, S; Wüst, R C I; Walsh, B et al. (2013) Increasing temperature speeds intracellular PO2 kinetics during contractions in single Xenopus skeletal muscle fibers. Am J Physiol Regul Integr Comp Physiol 304:R59-66
Breen, Ellen C; Malloy, Jaret L; Tang, Kechun et al. (2013) Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung. J Cell Physiol 228:371-9
Wray, D Walter; Nishiyama, Steven K; Donato, Anthony J et al. (2011) The paradox of oxidative stress and exercise with advancing age. Exerc Sport Sci Rev 39:68-76
Esposito, Fabio; Mathieu-Costello, Odile; Entin, Pauline L et al. (2010) The skeletal muscle VEGF mRNA response to acute exercise in patients with chronic heart failure. Growth Factors 28:139-47
Wray, D Walter; Nishiyama, Steve K; Donato, Anthony J et al. (2010) Human vascular aging: limb-specific lessons. Exerc Sport Sci Rev 38:177-85

Showing the most recent 10 out of 382 publications