Abstract

The chemistry core laboratory provides assays on a routine basis for individual projects within the program project. Established assays include measurements of renin activity, aldosterone, corticosterone, ANF, epinephrine, norepinephrine and ouabain. Projects which entail studies on potassium homeostasis in brain and fatty acid hypertension will use the chemistry core laboratory on a routine basis. The laboratory will assure quality control of the assays and provide consultation with individual investigators regarding appropriate use and interpretation of assays.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL018575-21
Application #
5213212
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Rocchini, Albert P; Yang, John Q; Smith, Marla J et al. (2010) Serial changes in norepinephrine kinetics associated with feeding dogs a high-fat diet. J Clin Hypertens (Greenwich) 12:117-24
Kamal, Mohamed A; Keep, Richard F; Smith, David E (2008) Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity. Drug Metab Pharmacokinet 23:236-42
Duan, Sheng Zhong; Ivashchenko, Christine Y; Whitesall, Steven E et al. (2007) Direct monitoring pressure overload predicts cardiac hypertrophy in mice. Physiol Meas 28:1329-39
Hu, Yongjun; Shen, Hong; Keep, Richard F et al. (2007) Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity. J Neurochem 103:2058-65
Ennis, Steven R; Keep, Richard F (2007) Effect of sustained-mild and transient-severe hyperglycemia on ischemia-induced blood-brain barrier opening. J Cereb Blood Flow Metab 27:1573-82
Shen, Hong; Ocheltree, Scott M; Hu, Yongjun et al. (2007) Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice. Drug Metab Dispos 35:1209-16
Xiang, Jianming; Chiang, Pei-Pei; Hu, Yongjun et al. (2006) Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures. Neurosci Lett 396:225-9
Ennis, S R; Keep, R F (2006) Effects of 2,4-dinitrophenol on ischemia-induced blood-brain barrier disruption. Acta Neurochir Suppl 96:295-8
Carello, Katari A; Whitesall, Steven E; Lloyd, Mary C et al. (2006) Asymmetrical dimethylarginine plasma clearance persists after acute total nephrectomy in rats. Am J Physiol Heart Circ Physiol 290:H209-16
Xiang, Jianming; Hu, Yongjun; Smith, David E et al. (2006) PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res 1122:18-23

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