National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Chicago
United States
Zip Code
Klezovitch, O; Edelstein, C; Scanu, A M (2001) Stimulation of interleukin-8 production in human THP-1 macrophages by apolipoprotein(a). Evidence for a critical involvement of elements in its C-terminal domain. J Biol Chem 276:46864-9
Simo, J M; Joven, J; Vilella, E et al. (2001) Impact of apolipoprotein(a) isoform size heterogeneity on the lysine binding function of lipoprotein(a) in early onset coronary artery disease. Thromb Haemost 85:412-7
Simo, J M; Joven, J; Vilella, E et al. (2001) Polymorphisms in human apolipoprotein(a) kringle IV-10 and coronary artery disease: relationship to allele size, plasma lipoprotein(a) concentration, and lysine binding site activity. J Mol Med 79:294-9
Edelstein, C; Nakajima, K; Pfaffinger, D et al. (2001) Oxidative events cause degradation of apoB-100 but not of apo[a] and facilitate enzymatic cleavage of both proteins. J Lipid Res 42:1664-70
Scanu, A M; Nakajima, K; Edelstein, C (2001) Apolipoprotein(a): structure and biology. Front Biosci 6:D546-54
Klezovitch, O; Formato, M; Cherchi, G M et al. (2000) Structural determinants in the C-terminal domain of apolipoprotein E mediating binding to the protein core of human aortic biglycan. J Biol Chem 275:18913-8
Fless, G M; Halfman, C J; Kirk, E W (2000) The relationship between the effect of lysine analogues and salt on the conformation of lipoprotein(a). Biochemistry 39:2740-7
Fless, G M; Kirk, E W; Klezovitch, O et al. (1999) Effect of phospholipase A2 digestion on the conformation and lysine/fibrinogen binding properties of human lipoprotein[a]. J Lipid Res 40:583-92
Edelstein, C; Shapiro, S D; Klezovitch, O et al. (1999) Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology. J Biol Chem 274:10019-23
Scanu, A M; Edelstein, C; Klezovitch, O (1999) Dominant role of the C-terminal domain in the binding of apolipoprotein(a) to the protein core of proteoglycans and other members of the vascular matrix. Trends Cardiovasc Med 9:196-200

Showing the most recent 10 out of 145 publications