Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL020592-10
Application #
3967580
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Hilber, Karlheinz; Sandtner, Walter; Zarrabi, Touran et al. (2005) Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channels. Biochemistry 44:13874-82
Sandtner, Walter; Szendroedi, Julia; Zarrabi, Touran et al. (2004) Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel. Mol Pharmacol 66:648-57
Undrovinas, Albertas I; Maltsev, Victor A; Kyle, John W et al. (2002) Gating of the late Na+ channel in normal and failing human myocardium. J Mol Cell Cardiol 34:1477-89
Hilber, Karlheinz; Sandtner, Walter; Kudlacek, Oliver et al. (2002) Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure? J Biol Chem 277:37105-15
Sunami, A; Glaaser, I W; Fozzard, H A (2001) Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics. Mol Pharmacol 59:684-91
Hilber, K; Sandtner, W; Kudlacek, O et al. (2001) The selectivity filter of the voltage-gated sodium channel is involved in channel activation. J Biol Chem 276:27831-9
Penzotti, J L; Lipkind, G; Fozzard, H A et al. (2001) Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis. Biophys J 80:698-706
Martin, R L; Lee, J H; Cribbs, L L et al. (2000) Mibefradil block of cloned T-type calcium channels. J Pharmacol Exp Ther 295:302-8
Sunami, A; Glaaser, I W; Fozzard, H A (2000) A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc Natl Acad Sci U S A 97:2326-31
Dudley Jr, S C; Chang, N; Hall, J et al. (2000) mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains. J Gen Physiol 116:679-90

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