Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL020592-17
Application #
3780051
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Hilber, Karlheinz; Sandtner, Walter; Zarrabi, Touran et al. (2005) Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channels. Biochemistry 44:13874-82
Sandtner, Walter; Szendroedi, Julia; Zarrabi, Touran et al. (2004) Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel. Mol Pharmacol 66:648-57
Undrovinas, Albertas I; Maltsev, Victor A; Kyle, John W et al. (2002) Gating of the late Na+ channel in normal and failing human myocardium. J Mol Cell Cardiol 34:1477-89
Hilber, Karlheinz; Sandtner, Walter; Kudlacek, Oliver et al. (2002) Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure? J Biol Chem 277:37105-15
Hilber, K; Sandtner, W; Kudlacek, O et al. (2001) The selectivity filter of the voltage-gated sodium channel is involved in channel activation. J Biol Chem 276:27831-9
Penzotti, J L; Lipkind, G; Fozzard, H A et al. (2001) Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis. Biophys J 80:698-706
Sunami, A; Glaaser, I W; Fozzard, H A (2001) Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics. Mol Pharmacol 59:684-91
Hanck, D A; Makielski, J C; Sheets, M F (2000) Lidocaine alters activation gating of cardiac Na channels. Pflugers Arch 439:814-21
Lipkind, G M; Fozzard, H A (2000) KcsA crystal structure as framework for a molecular model of the Na(+) channel pore. Biochemistry 39:8161-70
Martin, R L; Lee, J H; Cribbs, L L et al. (2000) Mibefradil block of cloned T-type calcium channels. J Pharmacol Exp Ther 295:302-8

Showing the most recent 10 out of 179 publications