Many of the mechanisms that underlie receptor-mediated endocytosis and the internalization of macromolecules from the cell surface or the extracellular space through coated pits were elucidated through analysis of the LDL receptor (LDLR). It is now clear that the LDLR is one member of a larger family of cell surface receptors that share the same overall structural organization, which is defined by the ordered arrangement of several conserved functional motifs (Figure 1). Although many members of this family interact with lipoproteins and other ligands related to lipid metabolism, most (with the exception of the LDLR) also bind ligands that are unrelated to lipid metabolism (1). Knockout experiments in mice suggest that LDLR family members are involved in cellular signal transduction events such as the transport of hormones and vitamins and the activation or modulation of cellular kinases, as shown by recent work from our lab and that of others (2, 3).

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL020948-34
Application #
8106522
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
34
Fiscal Year
2010
Total Cost
$580,011
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
DeBose-Boyd, Russell A; Ye, Jin (2018) SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond. Trends Biochem Sci 43:358-368
Brown, Michael S; Radhakrishnan, Arun; Goldstein, Joseph L (2018) Retrospective on Cholesterol Homeostasis: The Central Role of Scap. Annu Rev Biochem 87:783-807
Russell, David W (2018) Lucky, times ten: A career in Texas science. J Biol Chem 293:18804-18827
Que, Xuchu; Hung, Ming-Yow; Yeang, Calvin et al. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558:301-306
Stender, Stefan; Smagris, Eriks; Lauridsen, Bo K et al. (2018) Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride. Hepatology 67:2182-2195
Schumacher, Marc M; Jun, Dong-Jae; Johnson, Brittany M et al. (2018) UbiA prenyltransferase domain-containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids. J Biol Chem 293:312-323
Mitsche, Matthew A; Hobbs, Helen H; Cohen, Jonathan C (2018) Patatin-like phospholipase domain-containing protein 3 promotes transfer of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets. J Biol Chem 293:6958-6968
Banfi, Serena; Gusarova, Viktoria; Gromada, Jesper et al. (2018) Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice. Proc Natl Acad Sci U S A 115:E1249-E1258
Fine, Michael; Schmiege, Philip; Li, Xiaochun (2018) Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun 9:4192
Linden, Albert G; Li, Shili; Choi, Hwa Y et al. (2018) Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice. J Lipid Res 59:475-487

Showing the most recent 10 out of 766 publications