Abstract

The effects of hormones and nutrients on apolipoprotein metabolism will be examined by using three major animal models: (1) rat, (2) dog, and (3) patas monkey. The use of the three animal models will afford information on specific effects for the species versus general effects in mammalian lipoprotein physiology. The apolipoprotein and lipid composition of blood and peripheral lymph will be studied to determine the relationship between hormones, nutrients and lipoprotein metabolism in these media. Investigations of the processes will be conducted in animals with in vitro enzyme assays, liver perfusions, and cultured hepatocytes. New techniques in immunochemistry will be utilzed to expand our capabilities to study lipoprotein composition, metabolism and structure. These studies will provide a better understanding of the relationship between hormones, nutrients, and apolipoprotein metabolism in the blood and lymph. These results will help in our understanding of the development of atherosclerosis, its prevention and its treatment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL025596-08
Application #
3097888
Study Section
Heart, Lung, and Blood Research Review Committee B (HLBB)
Project Start
1980-04-01
Project End
1990-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
8
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Type
School of Medicine & Dentistry
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

DeLamatre, J G; Gabaldon, D M; Arnold, C S et al. (1998) Hepatic metabolism of oxidatively modified apo E-free high-density lipoproteins. Liver 18:264-71
Asztalos, B; Zhang, W; Roheim, P S et al. (1997) Role of free apolipoprotein A-I in cholesterol efflux. Formation of pre-alpha-migrating high-density lipoprotein particles. Arterioscler Thromb Vasc Biol 17:1630-6
Asztalos, B F; Lefevre, M; Foster, T A et al. (1997) Normolipidemic subjects with low HDL cholesterol levels have altered HDL subpopulations. Arterioscler Thromb Vasc Biol 17:1885-93
Hornick, C A; Hui, D Y; DeLamatre, J G (1997) A role for retrosomes in intracellular cholesterol transport from endosomes to the plasma membrane. Am J Physiol 273:C1075-81
Lee, L T; Scheer, W D; Thompson, J J (1996) Identification of cryptic peanut agglutinin-reactive sites in human lipoprotein(a). Biochim Biophys Acta 1302:79-83
Wong, L; Sivok, B; Kurucz, E et al. (1995) Lipid composition of HDL subfractions in dog plasma and lymph. Arterioscler Thromb Vasc Biol 15:1875-81
Asztalos, B F; Roheim, P S (1995) Presence and formation of 'free apolipoprotein A-I-like' particles in human plasma. Arterioscler Thromb Vasc Biol 15:1419-23
Fu, D; Hornick, C A (1995) Modulation of lipid metabolism at rat hepatic subcellular sites by female sex hormones. Biochim Biophys Acta 1254:267-73
de Beer, M C; Yuan, T; Kindy, M S et al. (1995) Characterization of constitutive human serum amyloid A protein (SAA4) as an apolipoprotein. J Lipid Res 36:526-34
Roheim, P S; Asztalos, B F (1995) Clinical significance of lipoprotein size and risk for coronary atherosclerosis. Clin Chem 41:147-52

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