Abstract

The objectives of the Core facility are: 1) to provide centralized facilities for exposing animals and cell cultures to intermitten hypoxia for investigations in all the projects; 2) to provide centralized facility for reagents, antibodies and restriction enzymes; 3) to share personnel for tissue processing as well as major equipment such as confocal microscope, electron microscope, 4) to share the cost and utilize effectively the data from micro array analysis; 5) to incorporate the experimental results into mathematical models that provide feedback for further refining the experimental design as well as hypotheses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL025830-21
Application #
6564830
Study Section
Project Start
2002-02-01
Project End
2006-12-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
21
Fiscal Year
2002
Total Cost
$266,956
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Prabhakar, Nanduri R; Semenza, Gregg L (2012) Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92:967-1003
Kline, David D (2010) Chronic intermittent hypoxia affects integration of sensory input by neurons in the nucleus tractus solitarii. Respir Physiol Neurobiol 174:29-36
Peng, Y-J; Nanduri, J; Yuan, G et al. (2009) NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci 29:4903-10
Kline, David D; Hendricks, Gabriel; Hermann, Gerlinda et al. (2009) Dopamine inhibits N-type channels in visceral afferents to reduce synaptic transmitter release under normoxic and chronic intermittent hypoxic conditions. J Neurophysiol 101:2270-8
Prabhakar, Nanduri R; Kumar, Ganesh K; Nanduri, Jayasri (2009) Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2. Ann N Y Acad Sci 1177:162-8
Braga, Valdir A; Prabhakar, Nanduri R (2009) Refinement of telemetry for measuring blood pressure in conscious rats. J Am Assoc Lab Anim Sci 48:268-71
Kline, David D (2008) Plasticity in glutamatergic NTS neurotransmission. Respir Physiol Neurobiol 164:105-11
Buniel, Maria; Glazebrook, Patricia A; Ramirez-Navarro, Angelina et al. (2008) Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body. J Comp Neurol 510:367-77
Pawar, Anita; Peng, Ying-Jie; Jacono, Frank J et al. (2008) Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia. J Appl Physiol 104:1287-94
Hsieh, Yee-Hsee; Dick, Thomas E; Siegel, Ruth E (2008) Adaptation to hypobaric hypoxia involves GABA A receptors in the pons. Am J Physiol Regul Integr Comp Physiol 294:R549-57

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