The purpose of this project is to develop and apply improved methods of myocardial perfusion quantitation, myocardial flow reserve and wall dynamics for the evaluation of the effects of coronary artery disease. The protocols emphasize flow quantitation using PET with applications to detection of dysfunctional reversibility and to quantitation of coronary perfusion reserve. A major hypothesis is that quantitative PET perfusion is able to show the likelihood that dysfunctional myocardial segments will recover following revascularization procedures and that perfusion quantitation is superior to fluorodeoxyglucose accumulation patterns or other contemporary non-invasive approached being used to assess viability. Forty patients who are to receive by-pass surgery will be studied. A new perfusion tracer using the 122Xe/122I generator could replace the need for an on site cyclotron and make Pet perfusion studies markedly more economical and practical in view of the new sources for 122Xe. The technological improvements in MRI could challenge PET methods for evaluation of ischemic heart disease and perfusion reserve thus these MRI methods will be compared to the best of the PET methods in years 4 and 5. Four cardiologists (three with the nuclear medicine specialty) and a cardiac radiologist have been included in addition to the medical scientist developing needed technology.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Lawrence Berkeley National Laboratory
United States
Zip Code
VanBrocklin, Henry F; Hanrahan, Stephen M; Enas, Joel D et al. (2007) Mitochondrial avid radioprobes. Preparation and evaluation of 7'(Z)-[125I]iodorotenone and 7'(Z)-[125I]iodorotenol. Nucl Med Biol 34:109-16
Maltz, Jonathan S; Budinger, Thomas F (2005) Evaluation of arterial endothelial function using transit times of artificially induced pulses. Physiol Meas 26:293-307
Marshall, Robert C; Powers-Risius, Patricia; Reutter, Bryan W et al. (2004) Kinetic analysis of 18F-fluorodihydrorotenone as a deposited myocardial flow tracer: comparison to 201Tl. J Nucl Med 45:1950-9
Huber, J S; Moses, W W; Jones, W F et al. (2002) Effect of 176Lu background on singles transmission for LSO-based PET cameras. Phys Med Biol 47:3535-41
Sitek, Arkadiusz; Gullberg, Grant T; Huesman, Ronald H (2002) Correction for ambiguous solutions in factor analysis using a penalized least squares objective. IEEE Trans Med Imaging 21:216-25
Qi, Jinyi; Huesman, Ronald H (2002) Scatter correction for positron emission mammography. Phys Med Biol 47:2759-71
Klein, Gregory J; Huesman, Ronald H (2002) Four-dimensional processing of deformable cardiac PET data. Med Image Anal 6:29-46
Maltz, Jonathan S (2002) Parsimonious basis selection in exponential spectral analysis. Phys Med Biol 47:2341-65
Reutter, B W; Gullberg, G T; Huesman, R H (2002) Effects of temporal modelling on the statistical uncertainty of spatiotemporal distributions estimated directly from dynamic SPECT projections. Phys Med Biol 47:2673-83
Marshall, R C; Powers-Risius, P; Reutter, B W et al. (2001) Kinetic analysis of 125I-iodorotenone as a deposited myocardial flow tracer: comparison with 99mTc-sestamibi. J Nucl Med 42:272-81

Showing the most recent 10 out of 55 publications