Core C Core C, The Database, Computing and Statistics Core is central to the functions of the Program Project. It receives data from the Sequencing and Microbiome profiling Core and the Biochemical and Metabolic Services Core. An existing PPG database will be extended to receive the new data proposed for collection during the next cycle. There will be two sources of human and mouse data: the Hybrid Mouse Diversity Panel and the MetSim cohort of 10,000 men from Finland. These data will be cleaned, managed and maintained for the three PPG projects, and each will use data from both sources. Statistical genetics and genomic analyses will be designed, conducted and interpreted to satisfy the respective Specific Aims. The Core will interact with each projection a regular basis in order to conduct analyses in the most efficient and effective manner possible. It will be responsible for: 1) data storage, management and retrieval, 2) conducting or teaching project members to conduct routine statistical analyses such as comparing gene expression levels under different conditions, and 3) novel analyses that require study design, statistical analyses and interpretation of results. The Core will take responsibility for achieving compliance with any NIH policies regarding data submission to publicly available databases as the NIH rules evolve.

Public Health Relevance

Core C Core C will receive a large amount of data from the Cores and Projects and will manage the data in coordination with them. It will analyze and teach project members to analyze their data, as appropriate. It will design and conduct novel analyses and discuss and interpret results with those conducting the projects.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL028481-32
Application #
9109007
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
32
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Miao, Zong; Alvarez, Marcus; Pajukanta, Päivi et al. (2018) ASElux: an ultra-fast and accurate allelic reads counter. Bioinformatics 34:1313-1320
Kurt, Zeyneb; Barrere-Cain, Rio; LaGuardia, Jonnby et al. (2018) Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease. Biol Sex Differ 9:46
Orozco, Luz D; Farrell, Colin; Hale, Christopher et al. (2018) Epigenome-wide association in adipose tissue from the METSIM cohort. Hum Mol Genet 27:1830-1846
Chella Krishnan, Karthickeyan; Kurt, Zeyneb; Barrere-Cain, Rio et al. (2018) Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. Cell Syst 6:103-115.e7
Freund, Malika Kumar; Burch, Kathryn S; Shi, Huwenbo et al. (2018) Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits. Am J Hum Genet 103:535-552
Pan, David Z; Garske, Kristina M; Alvarez, Marcus et al. (2018) Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS. Nat Commun 9:1512
Small, Kerrin S; Todor?evi?, Marijana; Civelek, Mete et al. (2018) Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition. Nat Genet 50:572-580
Mangul, Serghei; Yang, Harry Taegyun; Strauli, Nicolas et al. (2018) ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues. Genome Biol 19:36
Cantor, Rita; Navarro, Linda; Pan, Calvin (2018) Identifying fenofibrate responsive CpG sites. BMC Proc 12:43
Rahmani, Elior; Schweiger, Regev; Shenhav, Liat et al. (2018) BayesCCE: a Bayesian framework for estimating cell-type composition from DNA methylation without the need for methylation reference. Genome Biol 19:141

Showing the most recent 10 out of 518 publications