Abstract

The research objectives of this Program are to broadly evaluate mechanisms of arterial pressure regulation in normal and hypertensive states utilizing a variety of experimental and analytical techniques. Emphasis is placed on the control of body fluid volume by the kidney and mechanisms which determine systemic vascular smooth muscle tone. A special emphasis is placed on utilization of computer system analysis techniques to evaluate the complex interactions of cardiovascular function. The title of the specific projects proposed in this application best summarize the research to be performed, as follows: 1. Vasopressin Secretion and Cardiovascular Function. 2. Vasopressin in Essential Hypertension. 3. Direct Influence of Arterial Pressure on Renal Tubular Function. 4. Neural and Endocrine Control of Water and Electrolyte Balance. 5. Neural Control of Renal Function in Unanesthetized Animals. 6. Alteration of Vascular Muscle Tone and Bed Design in Small and Microcirculatory Vessels during Development of Spontaneous and Volume-Expanded Hypertension. 7. Cardiovascular System Integration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL029587-05
Application #
3098135
Study Section
Heart, Lung, and Blood Research Review Committee B (HLBB)
Project Start
1983-03-01
Project End
1988-02-29
Budget Start
1987-03-01
Budget End
1988-02-29
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226

  Publications

Fan, Fan; Roman, Richard J (2017) Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology. J Am Soc Nephrol 28:2845-2855
Fan, Fan; Pabbidi, Mallikarjuna R; Ge, Ying et al. (2017) Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries. Am J Physiol Renal Physiol 312:F971-F981
Cowley Jr, Allen W; Abe, Michiaki; Mori, Takefumi et al. (2015) Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension. Am J Physiol Renal Physiol 308:F179-97
Neuner, Sarah M; Wilmott, Lynda A; Hope, Kevin A et al. (2015) TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res 281:69-77
Rudemiller, Nathan P; Mattson, David L (2015) Candidate genes for hypertension: insights from the Dahl S rat. Am J Physiol Renal Physiol 309:F993-5
Rudemiller, Nathan; Lund, Hayley; Jacob, Howard J et al. (2014) CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Hypertension 63:559-64
He, Xiaofeng; Liu, Yong; Usa, Kristie et al. (2014) Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol 306:F1190-7
Lakshmikanthan, Sribalaji; Zieba, Bartosz J; Ge, Zhi-Dong et al. (2014) Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure. Arterioscler Thromb Vasc Biol 34:1486-94
Liu, Yong; Liu, Pengyuan; Yang, Chun et al. (2014) Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence. Hypertension 63:827-38
Fan, Fan; Sun, Cheng-Wen; Maier, Kristopher G et al. (2013) 20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels. PLoS One 8:e82482

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