Abstract

The overall objective of this Program is to evaluate broadly the mechaniss of arterial pressure regulation in normal and hypertensive states. Two major areas of study are emphasized: first, the regulation of body fluid volumes and electrolytes; second, the regulation of vascular smooth muscle tone and systemic vascular resistance. The Program integrates many levels of biological function ranging from cellular events to integrative mechanisms of the whole organism that ultimately determine arterial pressure. The conceptual framework of the Program has evolved from utilization of mathematical analysis (computer systems analysis) to evaluate the complex interactions of cardiovascular function.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL029587-09
Application #
2216484
Study Section
Heart, Lung, and Blood Research Review Committee B (HLBB)
Project Start
1983-03-01
Project End
1993-02-28
Budget Start
1991-03-01
Budget End
1992-02-29
Support Year
9
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Medical College of Wisconsin
Department
Physiology
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226

  Publications

Fan, Fan; Roman, Richard J (2017) Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology. J Am Soc Nephrol 28:2845-2855
Fan, Fan; Pabbidi, Mallikarjuna R; Ge, Ying et al. (2017) Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries. Am J Physiol Renal Physiol 312:F971-F981
Rudemiller, Nathan P; Mattson, David L (2015) Candidate genes for hypertension: insights from the Dahl S rat. Am J Physiol Renal Physiol 309:F993-5
Cowley Jr, Allen W; Abe, Michiaki; Mori, Takefumi et al. (2015) Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension. Am J Physiol Renal Physiol 308:F179-97
Neuner, Sarah M; Wilmott, Lynda A; Hope, Kevin A et al. (2015) TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res 281:69-77
Rudemiller, Nathan; Lund, Hayley; Jacob, Howard J et al. (2014) CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Hypertension 63:559-64
He, Xiaofeng; Liu, Yong; Usa, Kristie et al. (2014) Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol 306:F1190-7
Lakshmikanthan, Sribalaji; Zieba, Bartosz J; Ge, Zhi-Dong et al. (2014) Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure. Arterioscler Thromb Vasc Biol 34:1486-94
Liu, Yong; Liu, Pengyuan; Yang, Chun et al. (2014) Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence. Hypertension 63:827-38
Mattson, David L; Lund, Hayley; Guo, Chuanling et al. (2013) Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage. Am J Physiol Regul Integr Comp Physiol 304:R407-14

Showing the most recent 10 out of 455 publications