Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL030121-04
Application #
3968038
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Cassady, Kevin A; Gross, Martin (2002) The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain. J Virol 76:2029-35
Gupta, M; Mungai, P T; Goldwasser, E (2000) A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene. Blood 96:491-7
Kung, C; Fan, L; Goldwasser, E (2000) The role of tyrosine 15 in erythropoietin action. Arch Biochem Biophys 379:85-9
Gross, M; Hessefort, S; Olin, A (1999) Purification of a 38-kDa protein from rabbit reticulocyte lysate which promotes protein renaturation by heat shock protein 70 and its identification as delta-aminolevulinic acid dehydratase and as a putative DnaJ protein. J Biol Chem 274:3125-34
Cassady, K A; Gross, M; Roizman, B (1998) The second-site mutation in the herpes simplex virus recombinants lacking the gamma134.5 genes precludes shutoff of protein synthesis by blocking the phosphorylation of eIF-2alpha. J Virol 72:7005-11
Cassady, K A; Gross, M; Roizman, B (1998) The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2. J Virol 72:8620-6
He, B; Gross, M; Roizman, B (1998) The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells. J Biol Chem 273:20737-43
He, B; Gross, M; Roizman, B (1997) The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activa Proc Natl Acad Sci U S A 94:843-8
Picot, D; Loll, P J; Garavito, R M (1997) X-ray crystallographic study of the structure of prostaglandin H synthase. Adv Exp Med Biol 400A:107-11
Goldwasser, E (1996) Erythropoietin: a somewhat personal history. Perspect Biol Med 40:18-32

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