This program project competitive renewal consists of an integrated, multidisciplinary program including 3 closely related projects examining the progression of atherosclerosis and/or its amelioration, which is supported by 4 core units. Project 1, which would be conducted upon adolescents with persistently elevated blood pressure, would examine the effects of a behavioral intervention involving diet, exercise and stress management counseling. This project would assess the impact of the intervention on cardiovascular risk factors (e.g., lipid profiles, adiposity, inflammatory markers) and putative subclinical markers of disease (e.g., left ventricular mass, endothelial function). Project 2 would examine the effects of individual and group based cognitive behavior therapy (CBT) in acute myocardial infarction (AMI) patients who are at increased risk for medical morbidity and mortality after AMI because they are socially isolated or clinically depressed. Participants randomized into a CBT or usual care condition will be assessed in terms of biological risk factors (e.g., lipids, adiposity, coagulation factors) and possible subclinical markers of disease (e.g., carotid intima-media thickness, coronary calcification). The third project, which will be conducted on Watanabe Heritable Hyperlipidemic Rabbits (WHHL) will assess the role of: (a) the sympathetic nervous system (SNS) in behaviorally-related atherosclerosis; (b) corticotropin-releasing hormone in regulating SNS activity and progression of atherosclerosis during chronic social stress; (c) oxytocin (OT) in the hypothalamus as a function of social environment; and (d) OT in the regulation of hypothalamic pituitary adrenocortical and SNS activity in relation to the progression of behaviorally-related atherosclerosis. These 3 projects will each be supported by Administrative, Endocrinology and Metabolism, Cardiovascular Management and Statistics/Data Management units.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Study Section
Special Emphasis Panel (ZHL1-PPG-I (M2))
Program Officer
Kaufmann, Peter G
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University of Miami Coral Gables
Schools of Arts and Sciences
Coral Gables
United States
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Moncrieft, Ashley E; Llabre, Maria M; McCalla, Judith Rey et al. (2016) Effects of a Multicomponent Life-Style Intervention on Weight, Glycemic Control, Depressive Symptoms, and Renal Function in Low-Income, Minority Patients With Type 2 Diabetes: Results of the Community Approach to Lifestyle Modification for Diabetes Random Psychosom Med 78:851-60
Birnbaum-Weitzman, O; Goldberg, R; Hurwitz, B E et al. (2014) Depressive symptoms linked to 1-h plasma glucose concentrations during the oral glucose tolerance test in men and women with the metabolic syndrome. Diabet Med 31:630-6
Countryman, Amanda J; Saab, Patrice G; Schneiderman, Neil et al. (2014) Cardiovascular reactivity and cardiometabolic risk in adolescents. Int J Behav Med 21:122-30
Szeto, Angela; Rossetti, Maria A; Mendez, Armando J et al. (2013) Oxytocin administration attenuates atherosclerosis and inflammation in Watanabe Heritable Hyperlipidemic rabbits. Psychoneuroendocrinology 38:685-93
Chirinos, Diana A; Goldberg, Ronald; Gellman, Marc et al. (2013) Leptin and its association with somatic depressive symptoms in patients with the metabolic syndrome. Ann Behav Med 46:31-9
Noller, Crystal M; Szeto, Angela; Mendez, Armando J et al. (2013) The influence of social environment on endocrine, cardiovascular and tissue responses in the rabbit. Int J Psychophysiol 88:282-8
Hurwitz, Barry E (2012) Sleep Debt and Postprandial Metabolic Function in Subclinical Cardiometabolic Pathophysiology. Endocrinol Metab Syndr 1:
Raij, Leopoldo; Gonzalez-Ochoa, Alba M (2011) Vascular compliance in blood pressure. Curr Opin Nephrol Hypertens 20:457-64
Szeto, Angela; McCabe, Philip M; Nation, Daniel A et al. (2011) Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin. Psychosom Med 73:393-400
Nation, Daniel A; Szeto, Angela; Mendez, Armando J et al. (2010) Oxytocin attenuates atherosclerosis and adipose tissue inflammation in socially isolated ApoE-/- mice. Psychosom Med 72:376-82

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