This core is designed to provide cell lines, primary cell cultures, and tissues from hypertensive and normotensive animals for each of the projects. This core will also conduct routine molecular biological techniques which include assessment of message levels, quantitative PCR, etc. Other routine responsibilities include conducting electrophysiologic measures on cultured epithelial cells prior to distribution to various investigators, maintenance of quality control of routine culture, and cell isolation procedures. An additional objective of this core facility will be to produce and/or maintain various animal models with experimentally induced high blood pressure, (e.g. minipump Ang II infusion). This core will also oversee the breeding of transgenic mice and conduct genotyping. Blood pressures will be determined for hypertensive animal models.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
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Case Western Reserve University
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Huang, Chunfa; Miller, Richard Tyler (2010) Novel Ca receptor signaling pathways for control of renal ion transport. Curr Opin Nephrol Hypertens 19:106-12
Yu, Changqing; Yang, Zhiwei; Ren, Hongmei et al. (2009) D3 dopamine receptor regulation of ETB receptors in renal proximal tubule cells from WKY and SHRs. Am J Hypertens 22:877-83
Zeng, Chunyu; Asico, Laureano D; Yu, Changqing et al. (2008) Renal D3 dopamine receptor stimulation induces natriuresis by endothelin B receptor interactions. Kidney Int 74:750-9
Zeng, Chunyu; Armando, Ines; Luo, Yingjin et al. (2008) Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice. Am J Physiol Heart Circ Physiol 294:H551-69
Zeng, Chunyu; Villar, Van Anthony M; Eisner, Gilbert M et al. (2008) G protein-coupled receptor kinase 4: role in blood pressure regulation. Hypertension 51:1449-55
Resnick, Andrew; Hopfer, Ulrich (2008) Mechanical stimulation of primary cilia. Front Biosci 13:1665-80
Huang, Chunfa; Miller, R Tyler (2007) Regulation of renal ion transport by the calcium-sensing receptor: an update. Curr Opin Nephrol Hypertens 16:437-43
Ulmasov, Barbara; Bruno, Jonathan; Woost, Philip G et al. (2007) Tissue and subcellular distribution of CLIC1. BMC Cell Biol 8:8
Tandon, R; Levental, I; Huang, C et al. (2007) HIV infection changes glomerular podocyte cytoskeletal composition and results in distinct cellular mechanical properties. Am J Physiol Renal Physiol 292:F701-10
Huang, Chunfa; Sindic, Aleksandra; Hill, Ceredwyn E et al. (2007) Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function. Am J Physiol Renal Physiol 292:F1073-81

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