Abstract

The Peptide Core provides scientists of the Integrin Program Project with pure quantified synthetic peptides as they are requested. Some of the requested peptides are segments of natural proteins; some are isomers of these with scrambled sequences to serve as controls; some peptides are biologically active ligands; some are designed to contain an oligoproline or other region that should act as a framework for presentation of the ligand regions; and some contain novel amino-acid residues specifically synthesized by the Peptide Core for the Integrin Program Project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL045100-09
Application #
6472807
Study Section
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
Budget End
Support Year
9
Fiscal Year
2001
Total Cost
$110,268
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Wittchen, Erika S; Aghajanian, Amir; Burridge, Keith (2011) Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctions. Small GTPases 2:65-76
Demorest, Zachary L; MacDuff, Donna A; Brown, William L et al. (2010) The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination. PLoS One 5:e11660
Casiraghi, Monica; Tatreau, Jason R; Abano, John B et al. (2009) In vitro modeling of nonhypoxic cold ischemia-reperfusion simulating lung transplantation. J Thorac Cardiovasc Surg 138:760-7
Monaghan-Benson, Elizabeth; Burridge, Keith (2009) The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species. J Biol Chem 284:25602-11
Zanotti, Giorgio; Casiraghi, Monica; Abano, John B et al. (2009) Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Am J Physiol Lung Cell Mol Physiol 297:L52-63
Wittchen, Erika S (2009) Endothelial signaling in paracellular and transcellular leukocyte transmigration. Front Biosci (Landmark Ed) 14:2522-45
Sallee, Jennifer L; Burridge, Keith (2009) Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. J Biol Chem 284:14997-5006
Wang, Z; Holly, S P; Larson, M K et al. (2009) Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation. J Thromb Haemost 7:693-700
Aghajanian, Amir; Wittchen, Erika S; Campbell, Sharon L et al. (2009) Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif. PLoS One 4:e8045
Denofrio, Jan C; Yuan, Weiping; Temple, Brenda R et al. (2008) Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members. Thromb Haemost 100:847-56

Showing the most recent 10 out of 140 publications