The Peptide Core provides scientists of the Integrin Program Project with pure quantified synthetic peptides as they are requested. Some of the requested peptides are segments of natural proteins; some are isomers of these with scrambled sequences to serve as controls; some peptides are biologically active ligands; some are designed to contain an oligoproline or other region that should act as a framework for presentation of the ligand regions; and some contain novel amino-acid residues specifically synthesized by the Peptide Core for the Integrin Program Project.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL045100-10
Application #
6604769
Study Section
Project Start
2002-07-01
Project End
2003-06-30
Budget Start
Budget End
Support Year
10
Fiscal Year
2002
Total Cost
$110,268
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Wang, Z; Holly, S P; Larson, M K et al. (2009) Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation. J Thromb Haemost 7:693-700
Aghajanian, Amir; Wittchen, Erika S; Campbell, Sharon L et al. (2009) Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif. PLoS One 4:e8045
Denofrio, Jan C; Yuan, Weiping; Temple, Brenda R et al. (2008) Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members. Thromb Haemost 100:847-56

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