The overall goal of the proposed research is to investigate psychological and behavioral mechanisms that may be responsible for white coat hypertension. Based on the evidence from clinical observation studies, as well as the clear parallels to a vast psychology literature, or primary focus will be on stress and classical conditioning. To explore the possible roles of stress and classical conditioning in white coat hypertension, we propose a program of research that combines three complementary studies: 1) a longitudinal correlational study of relations between psychobehavioral variables and white coat hypertension; 2) an experimental study of cardiovascular responses to laboratory models of stress and conditioning; 3) a controlled clinical study of two experimental manipulations based on stress and classical conditioning theory. Three groups (n=150/group) of subjects (50% women) will be recruited: a) individuals clinically identified as having white coat hypertension (WCHT-Group), b) individuals clinically identified as having moderate established hypertension (EH-Group), c) individuals identified as being normotensive (NT-Group).
Specific Aim 1 : To investigate the relationships between white coat hypertension and psychological, and behavioral factors derived from stress and classical conditioning theory.
Specific Aim 3 : To test the causal relations between stress and classical conditioning predictors of white coat hypertension. The proposed research will be the first to concurrently investigate the contributions of stress and classical conditioning to the phenomenon of white coat hypertension. A greater understanding of those mechanisms may help provide guidance for the development of effective interventions with this population, including specific psychobehavioral interventions. Furthermore, the program of research may help to clarify the conflicting literature concerning potential pathogenic consequences of white coat hypertension.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL047540-06
Application #
6110125
Study Section
Project Start
1998-09-01
Project End
1999-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Type
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Bromfield, Samantha G; Booth 3rd, John N; Loop, Matthew S et al. (2018) Evaluating different criteria for defining a complete ambulatory blood pressure monitoring recording: data from the Jackson Heart Study. Blood Press Monit 23:103-111
Kronish, I M; Edmondson, D; Shimbo, D et al. (2018) A Comparison of the Diagnostic Accuracy of Common Office Blood Pressure Monitoring Protocols. Am J Hypertens :
Anstey, D Edmund; Muntner, Paul; Bello, Natalie A et al. (2018) Diagnosing Masked Hypertension Using Ambulatory Blood Pressure Monitoring, Home Blood Pressure Monitoring, or Both? Hypertension 72:1200-1207
Bello, Natalie A; Schwartz, Joseph E; Kronish, Ian M et al. (2018) Number of Measurements Needed to Obtain a Reliable Estimate of Home Blood Pressure: Results From the Improving the Detection of Hypertension Study. J Am Heart Assoc 7:e008658
Cornelius, Talea; Birk, Jeffrey L; Edmondson, Donald et al. (2018) Romantic Relationship Satisfaction and Ambulatory Blood Pressure During Social Interactions: Specificity or Spillover Effects? Ann Behav Med :
Cornelius, Talea; Birk, Jeffrey L; Edmondson, Donald et al. (2018) The joint influence of emotional reactivity and social interaction quality on cardiovascular responses to daily social interactions in working adults. J Psychosom Res 108:70-77
Shaffer, Jonathan A; Kronish, Ian M; Falzon, Louise et al. (2018) N-of-1 Randomized Intervention Trials in Health Psychology: A Systematic Review and Methodology Critique. Ann Behav Med 52:731-742
Taggart Wasson, Lauren; Shaffer, Jonathan A; Edmondson, Donald et al. (2018) Posttraumatic stress disorder and nonadherence to medications prescribed for chronic medical conditions: A meta-analysis. J Psychiatr Res 102:102-109
Edmondson, Donald; Sumner, Jennifer A; Kronish, Ian M et al. (2018) The Association of Posttraumatic Stress Disorder With Clinic and Ambulatory Blood Pressure in Healthy Adults. Psychosom Med 80:55-61
Diaz, Keith M; Krupka, David J; Chang, Melinda J et al. (2018) Wrist-based cut-points for moderate- and vigorous-intensity physical activity for the Actical accelerometer in adults. J Sports Sci 36:206-212

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