Abstract

Each of the projects include as a component the design, study, or use of gene targeted as well as normal mice or mouse tissues.
The aim of the core is to centralize and coordinate these activities, with streamlined generation of gene targeted chimeras, generation of mutant stocks, and histological analysis of mutant tissues. In this way all techniques relating to ES cell work, mouse stock maintenance, and tissue harvesting and analysis will be performed by a small number of people using standardized methods, under the supervision of a PI with specific experience in the field.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL048728-10
Application #
6503030
Study Section
Project Start
2001-09-01
Project End
2002-08-31
Budget Start
Budget End
Support Year
10
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Cantor, Joseph M; Rose, David M; Slepak, Marina et al. (2015) Fine-tuning Tumor Immunity with Integrin Trans-regulation. Cancer Immunol Res 3:661-7
Estrach, Soline; Lee, Sin-Ae; Boulter, Etienne et al. (2014) CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction. Cancer Res 74:6878-89
Kim, Chungho; Ye, Feng; Ginsberg, Mark H (2011) Regulation of integrin activation. Annu Rev Cell Dev Biol 27:321-45
Tzima, Ellie; Schimmel, Paul (2006) Inhibition of tumor angiogenesis by a natural fragment of a tRNA synthetase. Trends Biochem Sci 31:7-10
Goto, Shinya; Tamura, Noriko; Ishida, Hideyuki et al. (2006) Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling. J Am Coll Cardiol 47:155-62
Tzima, Eleni; Reader, John S; Irani-Tehrani, Mohamad et al. (2005) VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. J Biol Chem 280:2405-8
Mazzucato, Mario; Cozzi, Maria Rita; Pradella, Paola et al. (2004) Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow. Blood 104:3221-7
Baglia, Frank A; Shrimpton, Corie N; Emsley, Jonas et al. (2004) Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated platelet. J Biol Chem 279:49323-9
Kloeker, Susanne; Major, Michael B; Calderwood, David A et al. (2004) The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem 279:6824-33
Kasirer-Friede, Ana; Cozzi, Maria Rita; Mazzucato, Mario et al. (2004) Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors. Blood 103:3403-11

Showing the most recent 10 out of 142 publications