Abstract

AIMS: 1. To generate transgenic mice for the PPG investigators (by microinjection of DNA constructs into one-cell stage mouse embryos). 2. To establish cre and tet/R transgenic families that can be used to manipulate gene expression during cardiac development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL049953-07
Application #
6110221
Study Section
Project Start
1999-05-01
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
7
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Liu, Yu; Kaneda, Ruri; Leja, Thomas W et al. (2014) Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells. Stem Cells 32:1515-26
Zeve, Daniel; Seo, Jin; Suh, Jae Myoung et al. (2012) Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake. Cell Metab 15:492-504
Verzi, Michael P; Stanfel, Monique N; Moses, Kelvin A et al. (2009) Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology 136:1701-10
Shah, Viraj R; Koster, Maranke I; Roop, Dennis R et al. (2007) Double-inducible gene activation system for caspase 3 and 9 in epidermis. Genesis 45:194-9
Niu, Zhivy; Li, Ankang; Zhang, Shu X et al. (2007) Serum response factor micromanaging cardiogenesis. Curr Opin Cell Biol 19:618-27
Chang, Jiang; Xie, Min; Shah, Viraj R et al. (2006) Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A 103:14495-500
Zhang, Ying-Min; Bo, Jacqueline; Taffet, George E et al. (2006) Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis. FASEB J 20:916-25
Ilagan, Roger; Abu-Issa, Radwan; Brown, Doris et al. (2006) Fgf8 is required for anterior heart field development. Development 133:2435-45
Zhang, Shu Xing; Garcia-Gras, Eduardo; Wycuff, Diane R et al. (2005) Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation. J Biol Chem 280:19115-26
Vlahopoulos, Spiros; Zimmer, Warren E; Jenster, Guido et al. (2005) Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene. J Biol Chem 280:7786-92

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