Abstract

The task of the embryology core is to: (1) Analyze the expression pattern of genes in embryos and in particular in embryonic heart. This involved in situ hybridization on tissue sections and on whole-mounts. (2) Provide embryos, in particular chick embryos, to the PPG laboratories. (3) Train members of the PPG in the techniques of gene expression analysis. (4) To assist PPG investigators in documenting their results for the purpose of data analysis and publication.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL049953-10
Application #
6593867
Study Section
Project Start
2002-05-01
Project End
2003-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
2002
Total Cost
$175,153
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Liu, Yu; Kaneda, Ruri; Leja, Thomas W et al. (2014) Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells. Stem Cells 32:1515-26
Zeve, Daniel; Seo, Jin; Suh, Jae Myoung et al. (2012) Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake. Cell Metab 15:492-504
Verzi, Michael P; Stanfel, Monique N; Moses, Kelvin A et al. (2009) Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology 136:1701-10
Shah, Viraj R; Koster, Maranke I; Roop, Dennis R et al. (2007) Double-inducible gene activation system for caspase 3 and 9 in epidermis. Genesis 45:194-9
Niu, Zhivy; Li, Ankang; Zhang, Shu X et al. (2007) Serum response factor micromanaging cardiogenesis. Curr Opin Cell Biol 19:618-27
Chang, Jiang; Xie, Min; Shah, Viraj R et al. (2006) Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A 103:14495-500
Zhang, Ying-Min; Bo, Jacqueline; Taffet, George E et al. (2006) Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis. FASEB J 20:916-25
Ilagan, Roger; Abu-Issa, Radwan; Brown, Doris et al. (2006) Fgf8 is required for anterior heart field development. Development 133:2435-45
Niu, Zhiyv; Yu, Wei; Zhang, Shu Xing et al. (2005) Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem 280:32531-8
Chi, Xuan; Chatterjee, Pradeep K; Wilson 3rd, Willie et al. (2005) Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules. Proc Natl Acad Sci U S A 102:13490-5

Showing the most recent 10 out of 70 publications