Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL051818-04
Application #
2228775
Study Section
Special Emphasis Panel (ZHL1-CSR-K (S3))
Project Start
1993-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Goudy, Kevin S; Johnson, Mark C; Garland, Alaina et al. (2011) Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes. J Immunol 186:3779-86
Li, Wuping; Zhang, Liqun; Wu, Zhijian et al. (2011) AAV-6 mediated efficient transduction of mouse lower airways. Virology 417:327-33
Zhang, Liqun; Collins, Peter L; Lamb, Robert A et al. (2011) Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus. Virology 421:67-77
Johnson, Jarrod S; Gentzsch, Martina; Zhang, Liqun et al. (2011) AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis. PLoS Pathog 7:e1002053
Johnson, Jarrod S; Li, Chengwen; DiPrimio, Nina et al. (2010) Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction. J Virol 84:8888-902
Kwilas, Anna R; Yednak, Mark A; Zhang, Liqun et al. (2010) Respiratory syncytial virus engineered to express the cystic fibrosis transmembrane conductance regulator corrects the bioelectric phenotype of human cystic fibrosis airway epithelium in vitro. J Virol 84:7770-81
Mitchell, Angela M; Nicolson, Sarah C; Warischalk, Jayme K et al. (2010) AAV's anatomy: roadmap for optimizing vectors for translational success. Curr Gene Ther 10:319-340
Zhang, Liqun; Limberis, Maria P; Thompson, Catherine et al. (2010) ?-Fetoprotein gene delivery to the nasal epithelium of nonhuman primates by human parainfluenza viral vectors. Hum Gene Ther 21:1657-64
Zhang, Liqun; Button, Brian; Gabriel, Sherif E et al. (2009) CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium. PLoS Biol 7:e1000155
Li, Wuping; Zhang, Liqun; Johnson, Jarrod S et al. (2009) Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium. Mol Ther 17:2067-77

Showing the most recent 10 out of 36 publications