The biostatistics core's primary objective is to collaborate with investigators in each individual study throughout all phases of their research. We will provide support or be responsible for methodological, statistical and computer related issues including study design, sample size calculation and power analysis, randomization schedules, data collection instruments, data storage and retrieval, data analysis and manuscript preparation. The biostatistics core will be responsible for ensuring that each study design is adequate, including a clear definition of primary and secondary outcomes for each study, according to the hypothesis stated by the principal investigator's sample. There is assistance with sample size determination with specified Type I and Type II errors, provision of alternative methods to test hypothesis when the initial approach is not feasible relative to the pool of animals available and development of randomization schedules or sampling schemes for each study. The Core helps implement quality control measures common to all studies and provides methodological support to each project in developing new analytical techniques as needed and assisting in data analysis and interpretation of results as needed.
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