This Core provides computer, electronics, instrumentation and machine shop support services to the Program Project Gram Investigators. The services are an essemial part of the Projects' protocol design, animal maintenance, data acquisition and data analyses. Specific services range from creating instrumentation for acute and chronic animal experimemation to managing a World Wide Web server, to precision machining of custom mechanical parts. The personnel in this core are responsible for developing and implementing advances in microcomputer technology and software, and for developing new instrumentation to meet the research needs of the Program Project. Instrumentation and computer technologies developed by the various investigators are made available to all members of the Program Project team. Imaging support for immunohistochemical, densitometic, morphometric, and stereological analyses has been added by the Core during the previous grant period by the various projects as required for their experimental protocols. The Core will continue to increase the support for histological and immunohistochemical analyses during the next funding period. The Core will continue to support the development and use of mathematical modeling to as a quantitative way to test new and integrative physiological concepts.
| Brooks, Heddwen L; Lindsey, Merry L (2018) Guidelines for authors and reviewers on antibody use in physiology studies. Am J Physiol Heart Circ Physiol 314:H724-H732 |
| Aberdein, Nicola; Dambrino, Robert J; do Carmo, Jussara M et al. (2018) Role of PTP1B in POMC neurons during chronic high-fat diet: sex differences in regulation of liver lipids and glucose tolerance. Am J Physiol Regul Integr Comp Physiol 314:R478-R488 |
| Eddy, Adrian C; Bidwell 3rd, Gene L; George, Eric M (2018) Pro-angiogenic therapeutics for preeclampsia. Biol Sex Differ 9:36 |
| do Carmo, Jussara M; da Silva, Alexandre A; Moak, Sydney P et al. (2018) Role of melanocortin 4 receptor in hypertension induced by chronic intermittent hypoxia. Acta Physiol (Oxf) :e13222 |
| Lindsey, Merry L; Bolli, Roberto; Canty Jr, John M et al. (2018) Guidelines for experimental models of myocardial ischemia and infarction. Am J Physiol Heart Circ Physiol 314:H812-H838 |
| Chen, Xu; Li, Xuan; Zhang, Wenyan et al. (2018) Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-?B pathway. Metabolism 83:256-270 |
| Ma, Yonggang; Mouton, Alan J; Lindsey, Merry L (2018) Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction. Transl Res 191:15-28 |
| Mouton, Alan J; DeLeon-Pennell, Kristine Y; Rivera Gonzalez, Osvaldo J et al. (2018) Mapping macrophage polarization over the myocardial infarction time continuum. Basic Res Cardiol 113:26 |
| Meschiari, Cesar A; Jung, Mira; Iyer, Rugmani Padmanabhan et al. (2018) Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction. Am J Physiol Heart Circ Physiol 314:H224-H235 |
| Hinds Jr, Terry D; Stec, David E (2018) Bilirubin, a Cardiometabolic Signaling Molecule. Hypertension 72:788-795 |
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