The purpose of the Programming and Instrumentation Core will be to develop and maintain equipment and software for detectors, signal processing, data acquisition, experimental control, data analysis, and data backup and archiving. This is a necessary unit since the successful completion of all projects depends on sophisticated instrumentation, computer-based data acquisition and control, and streamlined analysis of data.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Moreno-Gonzalez, Alicia; Gillis, Todd E; Rivera, Anthony J et al. (2007) Thin-filament regulation of force redevelopment kinetics in rabbit skeletal muscle fibres. J Physiol 579:313-26
Kohler, Jan; Chen, Ying; Brenner, Bernhard et al. (2003) Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding. Physiol Genomics 14:117-28
Liang, Bo; Chen, Ying; Wang, Chien-Kao et al. (2003) Ca2+ regulation of rabbit skeletal muscle thin filament sliding: role of cross-bridge number. Biophys J 85:1775-86
Regnier, Michael; Rivera, Anthony J; Wang, Chien-Kao et al. (2002) Thin filament near-neighbour regulatory unit interactions affect rabbit skeletal muscle steady-state force-Ca(2+) relations. J Physiol 540:485-97
Martyn, D A; Chase, P B; Regnier, M et al. (2002) A simple model with myofilament compliance predicts activation-dependent crossbridge kinetics in skinned skeletal fibers. Biophys J 83:3425-34
LaMadrid, M A; Chase, P B; Gordon, A M (2002) Motility assays of calcium regulation of actin filaments. Results Probl Cell Differ 36:133-48
Martyn, D A; Regnier, M; Xu, D et al. (2001) Ca2+ - and cross-bridge-dependent changes in N- and C-terminal structure of troponin C in rat cardiac muscle. Biophys J 80:360-70
Mariano, A C; Alexandre, G M; Silva, L C et al. (2001) Dimethyl sulphoxide enhances the effects of P(i) in myofibrils and inhibits the activity of rabbit skeletal muscle contractile proteins. Biochem J 358:627-36
Regnier, M; Rivera, A J; Chen, Y et al. (2000) 2-deoxy-ATP enhances contractility of rat cardiac muscle. Circ Res 86:1211-7
Gordon, A M; Homsher, E; Regnier, M (2000) Regulation of contraction in striated muscle. Physiol Rev 80:853-924

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