Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL055552-02
Application #
5214402
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Solovey, Anna; Somani, Arif; Belcher, John D et al. (2017) A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade. Am J Hematol 92:1119-1130
Belcher, John D; Chen, Chunsheng; Nguyen, Julia et al. (2014) Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood 123:377-90
Shirodkar, Apurva V; St Bernard, Rosanne; Gavryushova, Anna et al. (2013) A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing. Blood 121:3531-40
Schaer, Dominik J; Buehler, Paul W; Alayash, Abdu I et al. (2013) Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood 121:1276-84
Nath, Karl A; Grande, Joseph P; Farrugia, Gianrico et al. (2013) Age sensitizes the kidney to heme protein-induced acute kidney injury. Am J Physiol Renal Physiol 304:F317-25
Mulrooney, Daniel A; Ness, Kirsten K; Huang, Sujuan et al. (2013) Pilot study of vascular health in survivors of osteosarcoma. Pediatr Blood Cancer 60:1703-8
Weber, M L; Chen, C; Li, Y et al. (2013) Morphine stimulates platelet-derived growth factor receptor-? signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo. Br J Anaesth 111:1004-12
Martin-Ramirez, Javier; Hofman, Menno; van den Biggelaar, Maartje et al. (2012) Establishment of outgrowth endothelial cells from peripheral blood. Nat Protoc 7:1709-15
Nath, Karl A (2012) Human AKI and heme oxygenase-1. J Am Soc Nephrol 23:971-4
Juskewitch, Justin E; Knudsen, Bruce E; Platt, Jeffrey L et al. (2012) LPS-induced murine systemic inflammation is driven by parenchymal cell activation and exclusively predicted by early MCP-1 plasma levels. Am J Pathol 180:32-40

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