Overview: This program project grant consists of a group of investigators from three different departments (Medicine, Pathology and Cellular and Molecular Medicine) and two institutions (The UCSD School of Medicine and nearby VA Medical Center). This Core consists of two components: a General Administrative component and a Mouse Management Component (MMC). The General Administrative Component will work to maintain the cohesiveness of the whole group and its functions by organizing group meetings, retreats and journal clubs, and by dealing with any and all inter-Departmental or inter-institutional issues that may arise. It will also organize internal and external reviews of the program, as well as make sure that renewal applications are submitted in a timely fashion. It will also track the financial status of the program on a monthly basis, and assist in hiring and other personnel issues. In addition, the Core will identify newly published literature relevant to the program, and distribute it to the appropriate investigators within the program. The goal of the administrative component is to make certain that the entire program functions as efficiently and optimally as possible. The Mouse Management Component (MMC) of this Core will include two full time animal technicians who are fully trained and engaged in the maintenance of gene-targeted and transgenic mouse models proposed in the individual projects. The MMC has the necessary equipment and space in a pathogen-free mouse-specific vivarium, as detailed below. The Core will play a key role in the breeding, husbandry, and dissemination of the mouse model systems described in this Program Project.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL057345-10
Application #
7510386
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
10
Fiscal Year
2007
Total Cost
$718,629
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Sato, Emi; Zhang, Ling-Juan; Dorschner, Robert A et al. (2017) Activation of Parathyroid Hormone 2 Receptor Induces Decorin Expression and Promotes Wound Repair. J Invest Dermatol 137:1774-1783
Johns, Scott C; Yin, Xin; Jeltsch, Michael et al. (2016) Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis. Circ Res 119:210-21
Mooij, Hans L; Bernelot Moens, Sophie J; Gordts, Philip L S M et al. (2015) Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans. J Lipid Res 56:665-73
Yin, Xin; Johns, Scott C; Kim, Daniel et al. (2014) Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol 192:2133-42
Chang, Yung-Chi; Olson, Joshua; Beasley, Federico C et al. (2014) Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog 10:e1003846
Schommer, Nina N; Muto, Jun; Nizet, Victor et al. (2014) Hyaluronan breakdown contributes to immune defense against group A Streptococcus. J Biol Chem 289:26914-21
Kawamura, Tetsuya; Stephens, Bryan; Qin, Ling et al. (2014) A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One 9:e81454
Muto, Jun; Morioka, Yasuhide; Yamasaki, Kenshi et al. (2014) Hyaluronan digestion controls DC migration from the skin. J Clin Invest 124:1309-19
Mooij, H L; Cabrales, P; Bernelot Moens, S J et al. (2014) Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function. J Am Heart Assoc 3:e001274
Xu, Ding; Young, Jeffrey H; Krahn, Juno M et al. (2013) Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol 8:1611-20

Showing the most recent 10 out of 140 publications