Core A (Administrative Core), led by the Program's Principal Investigator, Joe G. N. Garcia, MD, will provideessential administrative and secretarial support and ensure overall direction and organization of the entireProgram. In addition, this Core will provide accounting support that will ensure appropriate fiscal andscientific oversight, monitoring and compliance with federal and institutional grant management regulations,the latter through several formal mechanisms. The objectives of the Administrative core are (i) centralizationof all administrative actions and financial recording keeping, (ii) to provide statistical and data processingsupport for the projects (iii) to prepare scientific and financial reports as required by the university and theNHLBI, (iv) to ensure that the PPG research meets the highest standards through periodic review by theinternal and external review panels, (v) to facilitate the use of common resources, (vi) to foster exchange ofscientific information and ideas and (vi) provide the projects and cores with a review of all expenditures on amonthly basis and deal with University Accounting and Grants offices concerning grant budgets. Core A willcoordinate the inter-project, inter-departmental, and inter-institutional collaborative arrangements and evolvenew arrangements as deemed necessary for the scientific progress of the Program Project as a whole. Corepersonnel will orchestrate monthly meetings of the project leaders that will be held to discuss scientific andadministrative matters. Core A will organize regular research seminars on Monday mornings which will allowPPG investigators to present their work in progress to other researchers. Coordinated administrativeservices will ensure optimal purchasing practices, facilitate communications, and promote scientificinteraction.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL058064-13
Application #
7407791
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2008-02-01
Project End
2013-01-31
Budget Start
2008-02-01
Budget End
2009-01-31
Support Year
13
Fiscal Year
2008
Total Cost
$80,191
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Wang, Ting; Brown, Mary E; Kelly, Gabriel T et al. (2018) Myosin light chain kinase ( MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions. Pulm Circ 8:2045894018764171
Wang, X; Wang, L; Garcia, J G N et al. (2018) The Significant Role of c-Abl Kinase in Barrier Altering Agonists-mediated Cytoskeletal Biomechanics. Sci Rep 8:1002
Oita, Radu C; Camp, Sara M; Ma, Wenli et al. (2018) Novel Mechanism for Nicotinamide Phosphoribosyltransferase Inhibition of TNF-?-mediated Apoptosis in Human Lung Endothelial Cells. Am J Respir Cell Mol Biol 59:36-44
Szilágyi, Keely L; Liu, Cong; Zhang, Xu et al. (2017) Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome. Transl Res 180:12-21
Wang, X; Bleher, R; Wang, L et al. (2017) Imatinib Alters Agonists-mediated Cytoskeletal Biomechanics in Lung Endothelium. Sci Rep 7:14152
Shekhawat, Gajendra S; Dudek, Steven M; Dravid, Vinayak P (2017) Development of ultrasound bioprobe for biological imaging. Sci Adv 3:e1701176
Mascarenhas, Joseph B; Tchourbanov, Alex Y; Fan, Hanli et al. (2017) Mechanical Stress and Single Nucleotide Variants Regulate Alternative Splicing of the MYLK Gene. Am J Respir Cell Mol Biol 56:29-37
Belvitch, Patrick; Brown, Mary E; Brinley, Brittany N et al. (2017) The ARP 2/3 complex mediates endothelial barrier function and recovery. Pulm Circ 7:200-210
Camp, Sara M; Chiang, Eddie T; Sun, Chaode et al. (2016) ""Pulmonary Endothelial Cell Barrier Enhancement by Novel FTY720 Analogs: Methoxy-FTY720, Fluoro-FTY720, and ?-Glucuronide-FTY720"". Chem Phys Lipids 194:85-93
Rojo de la Vega, Montserrat; Dodson, Matthew; Gross, Christine et al. (2016) Role of Nrf2 and Autophagy in Acute Lung Injury. Curr Pharmacol Rep 2:91-101

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