Administrative Core Dr. James M. Wilson will serve as Director of the Administrative Core in his capacity as PI of the P01. Drs. Daniel J. Rader and Arthur Caplan are Associate Directors of this Core. The administrative home of the grant is the Gene Therapy Program (GTP) at Penn that is directed by Dr. Wilson. Administrative staff at GTP report to Dr. Wilson and will have complete responsibility for the administrative management of the P01. A number of mechanisms are in place to manage the science and interactions between the groups including an FH Team that is staffed with an experienced program manager and meets frequently. Several important internal and external committees provide oversight and advice including: Internal ? Shared Resource Committee of the School of Medicine that reviews the Vector Core annually, Management Committee of GTP that meets weekly; External - an External Scientific Advisory Committee and Ethics Advisory Board who meet with leadership of the P01 once per year.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL059407-20
Application #
9704026
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Fleg, Jerome L
Project Start
Project End
2021-05-31
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
20
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Amengual, Jaume; Guo, Liang; Strong, Alanna et al. (2018) Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100. Circ Res 122:568-582
Giles, April R; Sims, Joshua J; Turner, Kevin B et al. (2018) Deamidation of Amino Acids on the Surface of Adeno-Associated Virus Capsids Leads to Charge Heterogeneity and Altered Vector Function. Mol Ther 26:2848-2862
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Greig, Jenny A; Limberis, Maria P; Bell, Peter et al. (2017) Nonclinical Pharmacology/Toxicology Study of AAV8.TBG.mLDLR and AAV8.TBG.hLDLR in a Mouse Model of Homozygous Familial Hypercholesterolemia. Hum Gene Ther Clin Dev 28:28-38
Ajufo, Ezim; Cuchel, Marina (2016) Recent Developments in Gene Therapy for Homozygous Familial Hypercholesterolemia. Curr Atheroscler Rep 18:22
Ibrahim, Salam; Somanathan, Suryanarayan; Billheimer, Jeffrey et al. (2016) Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol. Cardiovasc Res 110:23-9

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