Abstract

The Molecular Embryology and Pathology Core will provide Projects 1,2,3,4 and 5 with routine and specialized molecular embryology and pathology facilities and services. This Core is planned to provide efficient and cost effective services. The projects share needs for embryonic, lung explant culture, in situ hybridization, immuno- histochemistry, microscopic imaging, photography, and stereology including computer three-dimensional reconstruction and morphometry as well as electron microscopy. This Core will provide routine and high quality organ explant culture services, and will provide centralized and cost effective histolog and photomicroscopy services as well as stereology and morphometry facilities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
3P01HL060231-02S2
Application #
6219113
Study Section
Project Start
1999-05-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
094878337
City
Los Angeles
State
CA
Country
United States
Zip Code
90027

  Publications

Buckley, Susan; Shi, Wei; Xu, Wei et al. (2015) Increased alveolar soluble annexin V promotes lung inflammation and fibrosis. Eur Respir J 46:1417-29
Xing, Yiming; Wang, Runming; Li, Changgong et al. (2015) PTEN regulates lung endodermal morphogenesis through MEK/ERK pathway. Dev Biol 408:56-65
Li, Changgong; Li, Aimin; Xing, Yiming et al. (2013) Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling. Dev Biol 378:13-24
Gong, Dapeng; Fei, Fei; Lim, Min et al. (2013) Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model. J Immunol 191:4514-20
Gong, Dapeng; Shi, Wei; Yi, Sun-ju et al. (2012) TGF? signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol 13:31
El-Hashash, Ahmed H K; Turcatel, Gianluca; Varma, Saaket et al. (2012) Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci 125:4036-48
Xu, Pinglong; Liu, Jianming; Derynck, Rik (2012) Post-translational regulation of TGF-* receptor and Smad signaling. FEBS Lett 586:1871-84
Tiozzo, Caterina; Danopoulos, Soula; Lavarreda-Pearce, Maria et al. (2012) Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer 19:111-122
Lamouille, Samy; Connolly, Erin; Smyth, James W et al. (2012) TGF-?-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci 125:1259-73
Xu, Pinglong; Liu, Jianming; Sakaki-Yumoto, Masayo et al. (2012) TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Sci Signal 5:ra34

Showing the most recent 10 out of 126 publications