The Translational Systems Core (Core C) will interface with the Project Leaders (Hammond, Insel, and? Montminy), Core A (Feramisco) and Core B (Miyanohara). This shared resource is designed to provide Program? scientists, in a single facility, specific techniques that are labor intensive, highly specialized, not generally? available to individual laboratories and expensive.? The specific translational systems provided by this Core include detailed cardiovascular physiological studies, the? development of cardiovascular disease models, and virus vector gene transfer methods. Physiological? assessment will include: 1) Transthoracic echocardiography to evaluate cardiac chamber size, wall thickness, and? function in vivo; 2) Assessment of contractile function of the heart, including measurement of the end-systolic? pressure-volume relationship; 3) The study of isolated perfused hearts, which will allow more refined and specific? measurements of LV contractility in a controlled setting isolated from complex reflex activation and adrenergic? activation associated with surgical preparations; 4) Telemetry to assess blood pressure and ECG in ambulatory? rodents.? In addition to providing these studies for all Program scientists, the Translational Systems Core will provide a? highly cost efficient means to conduct such studies in a centralized and well-equipped location, circumventing the? need for redundant efforts of individual participating laboratories. By consolidating physiological model? development and assessment and viral gene transfer, the cost savings will be considerable.
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