Abstract

The animal model core will function to provide animal models of in vivo angiogenesis and endothelial migration to each of the four projects. The models will include previously well described as well as more recently developed in vivo models. The pro- and anti-angiogenic factors as well as transgenic mice (back-crossed onto wild-type genetic backgrounds) to be studied in the Animal Model Core will be provided by the individual projects. The members of the Core Facility will perform the angiogenic protocols detailed below. All animal studies will be performed under animal protocols approved by the Weill Medical College Institutional Animal Care and Use Committee (IACUC) obtained by the PIs of each project and the Animal Model Core. Members of the Histology Core will perform the harvesting of tissues.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL067839-05
Application #
7073478
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2005-07-01
Budget End
2007-06-30
Support Year
5
Fiscal Year
2005
Total Cost
$234,491
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Type
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Morozova, Kateryna; Sridhar, Sunandini; Sidhar, Sunandini et al. (2015) Annexin A2 promotes phagophore assembly by enhancing Atg16L? vesicle biogenesis and homotypic fusion. Nat Commun 6:5856
Klenotic, Philip A; Page, Richard C; Li, Wei et al. (2013) Molecular basis of antiangiogenic thrombospondin-1 type 1 repeat domain interactions with CD36. Arterioscler Thromb Vasc Biol 33:1655-62
Klenotic, Philip A; Page, Richard C; Misra, Saurav et al. (2011) Expression, purification and structural characterization of functionally replete thrombospondin-1 type 1 repeats in a bacterial expression system. Protein Expr Purif 80:253-9
Ding, Bi-Sen; Nolan, Daniel J; Butler, Jason M et al. (2010) Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature 468:310-5
Rabbany, Sina Y; James, Daylon; Rafii, Shahin (2010) New dimensions in vascular engineering: opportunities for cancer biology. Tissue Eng Part A 16:2157-9
Yamamoto, Masaya; James, Daylon; Li, Hui et al. (2010) Generation of stable co-cultures of vascular cells in a honeycomb alginate scaffold. Tissue Eng Part A 16:299-308
Butler, Jason M; Kobayashi, Hideki; Rafii, Shahin (2010) Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. Nat Rev Cancer 10:138-46
Butler, Jason M; Nolan, Daniel J; Vertes, Eva L et al. (2010) Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell 6:251-64
Klenotic, Philip A; Huang, Ping; Palomo, Juan et al. (2010) Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin. Am J Pathol 176:2039-50
James, Daylon; Nam, Hyung-song; Seandel, Marco et al. (2010) Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent. Nat Biotechnol 28:161-6

Showing the most recent 10 out of 54 publications