The project is administered by the PI, the Program Administrator, Ms. Tolise Miles with the assistance of the Program Coordinator, Ms. Wing Kam Emily Chan. They provide the routine and strategic management for the administration of the Core. They oversee the finances of the project. The Core provides the interface between the scientific investigators and the purchasing, regulatory, and administrative requirements. The Core allocates the financial resources to individual subprojects and cores. It provides a monthly financial review for project and core leaders. It maintains a log of purchase order requests and receipt of supplies and equipment and for the tracking of expenditure, changes in personnel, and service contracts for the project leaders. It provides expert editorial assistance for preparation of manuscripts and word processing. It coordinates the convening of the internal and external scientific review groups. It handles the travel arrangements for the external review committee members and remuneration for their expenses. It coordinates the weekly research seminar, the monthly meeting of subproject and core leaders and faculty where data are presented and discussed and administrative plans are made and the visits of invited professors. The Core coordinates a biannual meeting on """"""""New insights into Cardiovascular Kidney Disease."""""""" This is a 3 day, small group program for opinion leaders in the US and overseas where selected topics from the program project are discussed in depth. The subproject and core leaders present their results and the external review group is invited to participate. This provides the reviewers with an opportunity to become deeply acquainted with the progress of the program and to provide their own comments on detail and substance. The meeting is financed by Division Funds. The Core prepares the reports and summaries which are required by the NIH for administrative review. The Core will support Xin (James) Li, Ph.D. as a biostatistician. He is skilled and experienced in the analysis of gene array data. He will provide statistical guidance and data interpretation to all investigators.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Special Emphasis Panel (ZHL1)
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Georgetown University
United States
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Li, Lingli; Lai, En Yin; Luo, Zaiming et al. (2018) High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass. Hypertension 72:1208-1216
Schmidt, Marcel Oliver; Garman, Khalid Ammar; Lee, Yong Gu et al. (2018) The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation. J Invest Dermatol 138:179-188
Tassi, Elena; Lai, En Yin; Li, Lingli et al. (2018) Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein). Hypertension 71:160-167
Tassi, Elena; Garman, Khalid A; Schmidt, Marcel O et al. (2018) Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism. Sci Rep 8:15973
Wang, Xiaoyan; Villar, Van Anthony; Tiu, Andrew et al. (2018) Dopamine D2 receptor upregulates leptin and IL-6 in adipocytes. J Lipid Res 59:607-614
Asico, Laureano D; Cuevas, Santiago; Ma, Xiaobo et al. (2018) Nephron segment-specific gene expression using AAV vectors. Biochem Biophys Res Commun 497:19-24
Tiu, Andrew C; Bishop, Michael D; Asico, Laureano D et al. (2017) Primary Pediatric Hypertension: Current Understanding and Emerging Concepts. Curr Hypertens Rep 19:70
Li, Lingli; Lai, En Yin; Luo, Zaiming et al. (2017) Superoxide and hydrogen peroxide counterregulate myogenic contractions in renal afferent arterioles from a mouse model of chronic kidney disease. Kidney Int 92:625-633
Diao, Zhenyu; Asico, Laureano D; Villar, Van Anthony M et al. (2017) Increased renal oxidative stress in salt-sensitive human GRK4?486V transgenic mice. Free Radic Biol Med 106:80-90
Yang, Jian; Jose, Pedro A; Zeng, Chunyu (2017) Gastrointestinal-Renal Axis: Role in the Regulation of Blood Pressure. J Am Heart Assoc 6:

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