Abstract

This Core is intended to integrate the disparate functions of a number of skilled personnel already present at the Children?s Hospital. Core B will provide pathology/histology collaboration for each investigator to determine any gross and microscopic abnormalities of the mouse models and changes in gene expression. Murine cardiovascular physiology, both noninvasive and invasive will also be provided. All of the Projects will use this core. The two Co-Directors, Dr. Melissa Colbert and Dr. Timothy Hewett, are expert in the fields of murine cardiac histology/embryology and murine physiology, respectively. Both have been involved in a number of important collaborations over the years with PPG personnel (see Introduction). Dr. Colbert will lead the histology/embryology facets of the Core while Dr. Hewett will direct the physiology component.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL069779-01
Application #
6606601
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2002-06-06
Project End
2007-04-30
Budget Start
2002-06-06
Budget End
2003-04-30
Support Year
1
Fiscal Year
2002
Total Cost
$305,975
Indirect Cost

  Institution

Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229

  Publications

Singh, Sonia R; Robbins, Jeffrey (2018) Desmin and Cardiac Disease: An Unfolding Story. Circ Res 122:1324-1326
Lowey, Susan; Bretton, Vera; Joel, Peteranne B et al. (2018) Hypertrophic cardiomyopathy R403Q mutation in rabbit ?-myosin reduces contractile function at the molecular and myofibrillar levels. Proc Natl Acad Sci U S A 115:11238-11243
Valiente-Alandi, Iñigo; Potter, Sarah J; Salvador, Ane M et al. (2018) Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure. Circulation 138:1236-1252
Meng, Qinghang; Bhandary, Bidur; Bhuiyan, Md Shenuarin et al. (2018) Myofibroblast-Specific TGF? Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy. Circ Res 123:1285-1297
Kamal, Fadia A; Travers, Joshua G; Schafer, Allison E et al. (2017) G Protein-Coupled Receptor-G-Protein ??-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure. J Am Soc Nephrol 28:197-208
Khalil, Hadi; Kanisicak, Onur; Prasad, Vikram et al. (2017) Fibroblast-specific TGF-?-Smad2/3 signaling underlies cardiac fibrosis. J Clin Invest 127:3770-3783
McLendon, Patrick M; Davis, Gregory; Gulick, James et al. (2017) An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels. Circ Res 121:604-616
Rudomanova, Valeria; Blaxall, Burns C (2017) Targeting GPCR-G??-GRK2 signaling as a novel strategy for treating cardiorenal pathologies. Biochim Biophys Acta Mol Basis Dis 1863:1883-1892
Molkentin, Jeffery D; Bugg, Darrian; Ghearing, Natasha et al. (2017) Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis. Circulation 136:549-561
Yutzey, Katherine E (2017) Cardiomyocyte Proliferation: Teaching an Old Dogma New Tricks. Circ Res 120:627-629

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