Abstract

The Apheresis Core is an integral part of the program project and will play a critical role in providingmononuclear and CD34+ cells for the projects in the Program Project Grant. The Apheresis Core willsupport the research projects by performing 3 specific functions: (1) It will provide critical expertise inapheresis cell collection, and subsequent cell processing, and cell storage; (2) it will provide the actualhuman MNCs and CD34+ cells in support of projects by Pober, Min, Tellides, and Bender; and (3) the Apheresis Core will provide additional blood samples and facilitate collection of blood samples for evaluation, as well as assisting in the injection of GCSF to stimulated donors who are recruited to provide CD34+ cells. The Apheresis Core willmaintain compliance with Institutional, NIH, FDA and National voluntary standard setting organizations(AABB, CAP, FACT) guidelines and will ensure that the protocols can be safely and effectively applied. TheCore will assure that nursing personnel are in compliance with all quality control standards, as well as withall accrediting agency requirements.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL070295-06
Application #
7297639
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2006-09-01
Project End
2011-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
6
Fiscal Year
2006
Total Cost
$153,952
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Kraehling, Jan R; Chidlow, John H; Rajagopal, Chitra et al. (2016) Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nat Commun 7:13516
Siragusa, Mauro; Fröhlich, Florian; Park, Eon Joo et al. (2015) Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation. Sci Signal 8:ra81
Lee, Monica Y; Luciano, Amelia K; Ackah, Eric et al. (2014) Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proc Natl Acad Sci U S A 111:12865-70
Pober, Jordan S; Jane-wit, Dan; Qin, Lingfeng et al. (2014) Interacting mechanisms in the pathogenesis of cardiac allograft vasculopathy. Arterioscler Thromb Vasc Biol 34:1609-14
Park, Eon Joo; Grabi?ska, Kariona A; Guan, Ziqiang et al. (2014) Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab 20:448-57
Wang, Chen; Yi, Tai; Qin, Lingfeng et al. (2013) Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. J Clin Invest 123:1677-93
Pober, Jordan S; Tellides, George (2012) Participation of blood vessel cells in human adaptive immune responses. Trends Immunol 33:49-57
Yi, Tai; Fogal, Birgit; Hao, Zhengrong et al. (2012) Reperfusion injury intensifies the adaptive human T cell alloresponse in a human-mouse chimeric artery model. Arterioscler Thromb Vasc Biol 32:353-60
Zhang, Jiasheng; Razavian, Mahmoud; Tavakoli, Sina et al. (2012) Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis. Arterioscler Thromb Vasc Biol 32:1849-55
Marin, Ethan P; Derakhshan, Behrad; Lam, TuKiet T et al. (2012) Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. Circ Res 110:1336-44

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