The Administrative Core provides the infrastructure and basic support for Projects I, II and III and Cores A and B to conduct their experiments and accomplish their research objectives. This core will serve as the common channel through which all scientific, administrative and fiscal communication occur to facilitate the exchange of information between project investigators and staff internally, as well as disseminating the findings of the projects and cores and communicating research advances to the public. The management of this multi-million dollar proposal requires intensive administrative, fiscal and grants management expertise, of which the Administrative Core has nearly a decade of experience in providing to the current and previous COAST PPGs. The Administrative Core has five main objectives: (1) to provide grant administration and grant management services to the three projects and 2 other cores, (2) to aid communication between individual projects and cores, (3) to facilitate the review of scientific progress and communication of experimental results, (4) to coordinate student experiences, media requests, and collaborative project contacts and follow-up, and (5) to manage the interacting efforts of the individual projects such as subject recruitment and retention, tissue storage, and data use and storage. Responsibilities of the Administrative Core include: contacting COAST families to schedule visits/procedures and reserve clinic rooms, participant payments and retention, tracking biologic specimens and archiving them appropriately, and maintaining regulatory/IRB approval of COAST study materials and banked tissue samples. In order to fulfill these objectives and roles, the staff of the Administrative Core will include the Principal Investigator (Dr. Lemanske), the Laboratory Manager (Christopher Tisler), an Administrative Program Specialist/Human Subjects Coordinator (Elizabeth Anderson) and a research specialist (Theresa Kang). Departmental support is also provided by a program assistant (Susan Costello).

Public Health Relevance

The Administrative Core provides the foundation to carry out the aims of this PPG and communicate its research advances to the public. Increasing public health awareness of COAST findings will be done through scientific publications, presentations, meetings, maintenance of the COAST website, and making banked tissue samples available to researchers to study areas beyond asthma.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
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Fiscal Year
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Indirect Cost
University of Wisconsin Madison
United States
Zip Code
Higano, Nara S; Spielberg, David R; Fleck, Robert J et al. (2018) Neonatal Pulmonary Magnetic Resonance Imaging of Bronchopulmonary Dysplasia Predicts Short-Term Clinical Outcomes. Am J Respir Crit Care Med 198:1302-1311
Stein, Michelle M; Thompson, Emma E; Schoettler, Nathan et al. (2018) A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol 142:749-764.e3
Bønnelykke, Klaus; Coleman, Amaziah T; Evans, Michael D et al. (2018) Cadherin-related Family Member 3 Genetics and Rhinovirus C Respiratory Illnesses. Am J Respir Crit Care Med 197:589-594
Bashir, Hiba; Grindle, Kristine; Vrtis, Rose et al. (2018) Association of rhinovirus species with common cold and asthma symptoms and bacterial pathogens. J Allergy Clin Immunol 141:822-824.e9
Higano, Nara S; Bates, Alister J; Tkach, Jean A et al. (2018) Pre- and post-operative visualization of neonatal esophageal atresia/tracheoesophageal fistula via magnetic resonance imaging. J Pediatr Surg Case Rep 29:5-8
Higano, Nara S; Hahn, Andrew D; Tkach, Jean A et al. (2017) Retrospective respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Magn Reson Med 77:1284-1295
Barkal, Layla J; Procknow, Clare L; Álvarez-García, Yasmín R et al. (2017) Microbial volatile communication in human organotypic lung models. Nat Commun 8:1770
Higano, Nara S; Fleck, Robert J; Spielberg, David R et al. (2017) Quantification of neonatal lung parenchymal density via ultrashort echo time MRI with comparison to CT. J Magn Reson Imaging 46:992-1000
Anderson, Halie M; Jackson, Daniel J (2017) Microbes, allergic sensitization, and the natural history of asthma. Curr Opin Allergy Clin Immunol 17:116-122
Kloepfer, Kirsten M; Sarsani, Vishal K; Poroyko, Valeriy et al. (2017) Community-acquired rhinovirus infection is associated with changes in the airway microbiome. J Allergy Clin Immunol 140:312-315.e8

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